Many dermatological diseases are accompanied by oxidative stress and natural antioxidants are used in dermatology and cosmetology. The efforts to use synthetic antioxidants for skin care and treatment are practically absent. That is why we select for this investigation new topical formulation of ethylmethylhydroxypyridine succinate (EMHPS), a synthetic antioxidant. The objective is to study the status of lipid peroxidation and antioxidant protection in the blood of animals with experimental dermatologic pathology under the influence of the EMHPS gel topical use. There were three series of experiments on 125 adults male Wistar rats with chemical depilation, acute ultraviolet skin damage and psoriatic-like dermatitis. The 5% EMHPS gel was applied to the skin in a dose of 125 mg/kg. The duration of treatment was 21 days after chemical depilation, 3 days after ultraviolet irradiation, and 6 days after the induction of imiquimod dermatitis. The animals were euthanized in different moments of the experiments and the malondialdehyde (MDA) concentration, superoxide dismutase (SOD) and catalase activities were determined in the blood. The data were statistically processed by ANOVA method with a post-hoc Tukey test. Obtained results confirmed that local pathological processes of an inflammatory nature in the skin of laboratory animals, modeled as chemical depilation, ultraviolet irradiation, and psoriatic-like dermatitis, are accompanied by oxidative stress at the level of the whole organism with the manifestation in the blood. In the recovering period after chemical depilation, the EMHPS gel reduced the MDA concentration in the blood and increased the SOD and catalase activity in 3, 9 and 21 days after depilation. On the background of ultraviolet irradiation, the studied gel inhibited the MDA accumulation in the blood 2 and 3 days after and reduced the SOD activity 1 day after the exposure. In the developed imiquimod-induced dermatitis, the EMHPS gel lowered the MDA concentration in the blood and enhanced the catalase activity to the end of treatment. Therefore, the 5% EMHPS gel used topically, produced an antioxidant effect at the systemic level, which, given neuro- and organoprotective properties and low toxicity of EMHPS, is a positive aspect of experimental therapy for dermatological pathology.
Keywords: Oxidative Stress; Antioxidant; Ethylmethylhydroxypyridine Succinate; Gel; Skin Disease Animal Model; Systemic Effect
Elena Vazhnichaya., et al. “Systemic Effect of the Antioxidant Gel in Experimental Dermatologic Pathology” ”. EC Pharmacology and Toxicology 12.12 (2024): 01-09.
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