EC Pharmacology And Toxicology

Vachellia jacquemontii (Benth.) Ali commonly known as Acacia jacquemontii and Jacquemont's acacia is locally to the Thar Desert of India and Pakistan. This herb has been used traditionally for a variety of medical conditions, such as chronic renal disease, rheumatism, joint discomfort, snakebite, fever and abortion induction. Vachellia jacquemontii (Benth.) Ali's stem is important because of its rich phytochemical profile, which calls for a careful Pharmacognostical analysis. Numerous pharmacological and biological characteristics, including anti-inflammatory, anti-bacterial, antihypertensive, antiplatelet, hypoglycemic, anti-atherosclerotic, anticancer, analgesic, free radical scavenging, and antioxidant qualities, are well-known for Vachellia jacquemontii (Benth.) Ali. The complex phytochemical profile of Vachellia jacquemontii depends on its stem, which calls for a careful analysis. Pharmacognostical standardization of the stem of Vachellia jacquemontii is the aim of this investigation.

Studies of the Vachellia jacquemontii stem's morphology and histology are part of the standardization process. The plant's physiochemical analyses, which included measurements of its ash value, moisture content, and pH, were in line with pharmacopoeial standards and reports. These findings show that the medicine is of adequate quality and satisfies all recommended parameters. Proteins, alkaloids, amino acids, saponins, flavonoids, and other phenolic compounds were found in the plant extracts after phytochemical screening; glycosides, sterols, carbohydrates and volatile oils were not found.

EEVJ had a high content of total flavonoids (191.09 ± 1.232 quercetin equivalents mg/g of EEVJ) and a low content of total phenolics (42.13 ± 1.704 tannic acid equivalents mg/g of EEVJ), according to quantitative estimate of phytoconstituent, specifically total flavonoids and total phenolics. The results of the Pharmacognostical standardization of Vachellia jacquemontii (Benth.) Ali indicates that stem plays an important role in both conventional medicine and contemporary therapies. Combining phytochemical profiling and morphological evaluations allows for the establishment of thorough standards that maintain traditional knowledge systems while guaranteeing consumer safety and efficacy.

 Keywords: Acacia jacquemontii; Pharmacognostical Standardization; Total Flavonoids and Total Phenolics Content; Antiplatelet; Hypoglycemic

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