EC Pharmacology And Toxicology

Sleep, a fundamental regulator of neuroendocrine function and glucose metabolism, has been associated with metabolic and endocrine alterations. Sleep deprivation leads to decreased glucose tolerance, insulin sensitivity, and elevated cortisol levels in the evenings, increased ghrelin, decreased leptin, and heightened hunger and appetite. Recent epidemiological and laboratory evidence supports previous findings, suggesting a connection between sleep loss and an increased risk of obesity. Obesity, resulting from a calorie imbalance, significantly impacts quality of life and elevates the risk of various diseases. Insufficient sleep and circadian misalignment contribute to obesity by disrupting appetite hormones and energy expenditure. Millions worldwide face challenges in obtaining sufficient sleep due to modern lifestyles and technological advancements, affecting metabolic functions and body weight regulation. Sleep is essential in regulating physiological functions and influencing behavior, development, and overall health. Sleep deprivation and disorders are linked to obesity and may hinder weight loss efforts. Studies demonstrate that sleep restriction disrupts energy balance. Hence, use of natural remedies for treating insomnia might be an effective therapy in controlling insomnia associated overweight and obesity.

 Keywords: Orexin System; Insomnia; Obesity; Ghrelin; Leptin; Natural Herbs

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