EC Pharmacology And Toxicology

Introduction: Apasmara is the disease in which the Smaranshakti (Recollection) gets vitiated/affected. It is a disease due to vitiation Sharirik doshas as well as Manasik doshas. Most of the clinical presentation of Apasmara resembles with epilepsy/seizure disorder. Various pharmaceutical preparations, including Ghee or oil (Snehakalpana), are mentioned in Ayurveda to combat Apasmara, the ‘Ghrita Kalpana’ is one of these. In addition to the adverse reactions of synthetic antiepileptic drugs (AEDs), several ‘Ghrita Kalpana’ are used to treat seizures; it showed favourable results and aids in maintaining overall health. ‘Saindhavadhi Ghrita’ is a proprietary ayurvedic formulation advised to aid in the management of several kinds of psychological conditions, especially in Apasmara mentioned in Yogaratnakara.

Aim: To rationalize the use of Saindhavadhi Ghrita in the management of Apasmara (Epilepsy).

Methodology: Critical systematic review on efficacy of Saindhavadhi Ghrita in Apasmara based on the action of each ingredient, extensive literature search in both print and electronic media.

Result: Data will be critically analysed based on probable mode of action, all the ingredients of Saindhavadhi Ghrita having neuroprotective as well as enhances the Medhya activity, so it will be effective in the management of Apasmara.

Discussion: ‘Smriti-Naasha (memory loss)’ is the primary cause of the disease Apasmara. By enhancing Buddhi, Smriti, and correcting Mana’s disturbance, ‘Saindhavadhi Ghrita’ have a specific impact on mental health.

 Keywords: Apasmara; Ghrita Kalpana; Saindhavadhi Ghrita

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