EC Nutrition

‘Good fences’ is lifted, of course, from Robert Frost’s sinewy poem Mending Wall. Written in 1914, as fences were starting to fall across Europe, Africa and the Middle East, it reflects an elemental truth. Diversity may or may not be strength but division definitely is definition, identity, integrity and function. And so it is in us.

 Keywords: Food Supply Chain; Climate Change; Artificial Intelligence; Business Models; Global Circular Debt; Covid 19 Pandemic; Natural Health; Science Principles; Food as Medicine; Microbiota; Commensals; Gut Barrier; Mucous Layer; Blood Brain Barrier; Allergy; Autoimmunity

1. Oktedalen O., et al. “Changes in the gastrointestinal mucosa after long-distance running”. Scandinavian Journal of Gastroenterology 4 (1992): 270-274.
2. Salgado R and Moseley P. “The effects of acute oral glutamine supplementation on exercise-induced gastrointestinal permeability and heat shock protein expression in peripheral blood mononuclear cells”. Cell Stress and Chaperones 1 (2015): 85-93.
3. Dharmani P., et al. “Role of intestinal mucins in innate host defense mechanisms against pathogens”. Journal of Innate Immunity 2 (2009): 123-135.
4. Yang WH., et al. “Innate mechanism of mucosal barrier erosion in the pathogenesis of acquired colitis”. iScience10 (2023): 107883.
5. https://drpaulclayton.eu/blog/the-mandible-claw/
6. Spragge F., et al. “Microbiome diversity protects against pathogens by nutrient blocking”. Science 6676 (2023): eadj3502.
7. Crouch LI., et al. “Prominent members of the human gut microbiota express endo-acting O-glycanases to initiate mucin breakdown”. Nature Communications 1 (2020): 4017.
8. Johansson ME., et al. “Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis”. Gut2 (2014): 281-291.
9. van der Post S., et al. “Structural weakening of the colonic mucus barrier is an early event in ulcerative colitis pathogenesis”. Gut12 (2019): 2142-2151.
10. Gao J., et al. “A novel postbiotic from Lactobacillus rhamnosus GG with a beneficial effect on intestinal barrier function”. Frontiers in Microbiology 10 (2019): 477.
11. Zhu X., et al. “Intestinal microbiota regulates the gut-thyroid axis: the new dawn of improving Hashimoto thyroiditis”. Clinical and Experimental Medicine 1 (2024): 39.
12. Ghosh S., et al. “Regulation of intestinal barrier function by microbial metabolites”. Cellular and Molecular Gastroenterology and Hepatology 5 (2021): 1463-1482.
13. Rodrigues VF., et al. “Akkermansia muciniphila and gut immune system: a good friendship that attenuates inflammatory bowel disease, obesity, and diabetes”. Frontiers in Immunology 13 (2022): 934695.
14. Raygoza Garay JA., et al. “Gut microbiome composition is associated with future onset of crohn's disease in healthy first-degree relatives”. Gastroenterology3 (2023): 670-681.
15. Chen L., et al. “Genetic and microbial associations to plasma and fecal bile acids in obesity relate to plasma lipids and liver fat content”. Cell Reports 1 (2020): 108212.
16. Liévin-Le Moal V and Servin AL. “Anti-infective activities of lactobacillus strains in the human intestinal microbiota: from probiotics to gastrointestinal anti-infectious biotherapeutic agents”. Clinical Microbiology Reviews 2 (2014): 167-199.
17. Raygoza Garay JA., et al. “Gut microbiome composition is associated with future onset of crohn's disease in healthy first-degree relatives”. Gastroenterology3 (2023): 670-681.
18. Guo H., et al. “Urban-rural disparities and temporal trends in peptic ulcer disease epidemiology, treatment, and outcomes in the United States”. American Journal of Gastroenterology 2 (2021): 296-305.
19. Zamolodchikova TS., et al. “Cathepsin G-not only inflammation: the immune protease can regulate normal physiological processes”. Frontiers in Immunology 11 (2020): 411.
20. Zamolodchikova TS., et al. “Cathepsin G in the immune defense of the human duodenum: new sources for biosynthesis”. Human Physiology 43 (2017): 326-333.
21. Discussion and correspondence with Dr Charles Akle.
22. https://drpaulclayton.eu/blog/autoimmunity
23. Strachan DP. “Hay fever, hygiene, and household size”. British Medical Journal 6710 (1989): 1259-1260.
24. Rook GA., et al. “Microbial 'Old Friends', immunoregulation and stress resilience”. Evolution, Medicine, and Public Health 1 (2013): 46-64.
25. https://drpaulclayton.eu/blog/innately-trained/
26. Khan R., et al. “Commensal bacteria: an emerging player in defense against respiratory pathogens”. Frontiers in Immunology 10 (2019): 1203.
27. Daley D. “The evolution of the hygiene hypothesis: the role of early-life exposures to viruses and microbes and their relationship to asthma and allergic diseases”. Current Opinion in Allergy and Clinical Immunology 5 (2014): 390-396.
28. Shapiro K., et al. “Healthcare-associated infections caused by Mycolicibacterium neoaurum”. Emerging Infectious Diseases 8 (2023): 1516-1523.
29. Nouioui I and Dye T. “Heat-killed Mycolicibacterium aurum Aogashima: An environmental nonpathogenic actinobacteria under development as a safe novel food ingredient”. Food Science and Nutrition 9 (2021): 4839-4854.
30. https://food.ec.europa.eu/system/files/2021-02/novel-food_sum_ongoing-app_2020-1827.pdf
31. Bazzi S., et al. “Analysis of the immunomodulatory properties of two heat-killed mycobacterial preparations in a human whole blood model”. Immunobiology12 (2015): 1293-1304.
32. Bazzi S., et al. “Immunomodulatory effects of heat-killed Mycobacterium obuense on human blood dendritic cells”. Innate Immunity 7 (2017): 592-605.
33. Holbrook EM., et al. “Mycobacterium vaccae NCTC 11659, a soil-derived bacterium with stress resilience properties, modulates the proinflammatory effects of LPS in macrophages”. International Journal of Molecular Sciences 6 (2023): 5176.
34. Frank MG., et al. “Immunization with Mycobacterium vaccae induces an anti-inflammatory milieu in the CNS: Attenuation of stress-induced microglial priming, alarmins and anxiety-like behavior”. Brain, Behavior, and Immunity 73 (2018): 352-363.
35. Jin J., et al. “The structure and function of the glycocalyx and its connection with blood-brain barrier”. Frontiers in Cellular Neuroscience 15 (2021): 739699.
36. Takata F., et al. “Blood-brain barrier dysfunction amplifies the development of neuroinflammation: understanding of cellular events in brain microvascular endothelial cells for prevention and treatment of BBB dysfunction”. Frontiers in Cellular Neuroscience 15 (2021): 661838.
37. Zheng ZH., et al. “Neuroinflammation induces anxiety- and depressive-like behavior by modulating neuronal plasticity in the basolateral amygdala”. Brain, Behavior, and Immunity 91 (2021): 505-518.
38. Maydych V. “The interplay between stress, inflammation, and emotional attention: relevance for depression”. Frontiers in Neuroscience 13 (2019): 384.
39. https://drpaulclayton.eu/blog/hothead/
40. Liu YZ., et al. “Inflammation: The common pathway of stress-related diseases”. Frontiers in Human Neuroscience 11 (2017): 316.
41. Miller MW., et al. “Oxidative stress, inflammation, and neuroprogression in chronic PTSD”. Harvard Review of Psychiatry 2 (2018): 57-69.
42. Jacka FN., et al. “Association of Western and traditional diets with depression and anxiety in women”. American Journal of Psychiatry 3 (2010): 305-311.
43. Zhang H., et al. “Association between Western dietary patterns, typical food groups, and behavioral health disorders: an updated systematic review and meta-analysis of observational studies”. Nutrients1 (2023): 125.
44. Kim MJ., et al. “Associations of healthy eating behavior with mental health and health-related quality of life: results from the Korean national representative survey”. Nutrients24 (2023): 5111.
45. Jiménez-López E., et al. “Adherence to the Mediterranean diet and depressive, anxiety, and stress symptoms in Spanish adolescents: results from the EHDLA study”. European Child and Adolescent Psychiatry (2024).
46. Flandroy L., et al. “The impact of human activities and lifestyles on the interlinked microbiota and health of humans and of ecosystems”. Science of the Total Environment 627 (2018): 1018-1038.
47. Mazzari G., et al. “Subcutaneous Mycobacterium vaccae ameliorates the effects of early life adversity alone or in combination with chronic stress during adulthood in male and female mice”. Neurobiology of Stress 26 (2023): 100568.
48. Reber SO., et al. “Immunization with a heat-killed preparation of the environmental bacterium Mycobacterium vaccae promotes stress resilience in mice”. Proceedings of the National Academy of Sciences of the United States of America 22 (2016): E3130-E3139.
49. Hassell JE., et al. “Immunization with a heat-killed preparation of Mycobacterium vaccae NCTC 11659 enhances auditory-cued fear extinction in a stress-dependent manner”. Brain, Behavior, and Immunity 107 (2023): 1-15.
50. Lowry CA., et al. “Identification of an immune-responsive mesolimbocortical serotonergic system: potential role in regulation of emotional behavior”. Neuroscience2 (2007): 756-772.
51. Weiss Anna-Lena J. “Promoting stress resilience by the administration of a heat-killed preparation of Mycolicibacterium aurum Aogashima in a mouse model of chronic psychosocial stress”. Open Access Repositorium der Universität Ulm und Technischen Hochschule Ulm. Dissertation (2022).
52. Kesebir S and Kesebir P. “A growing disconnection from nature is evident in cultural products”. Perspectives on Psychological Science 2 (2017): 258-269.
53. Greenberg G. “Manufacturing depression: The secret history of a modern disease”.
54. Jimenez MP., et al. “Associations between nature exposure and health: a review of the evidence”. International Journal of Environmental Research and Public Health 9 (2021): 4790.
55. Roberts H., et al. “The effect of short-term exposure to the natural environment on depressive mood: A systematic review and meta-analysis”. Environmental Research 177 (2019): 108606.
56. Bratman GN., et al. “Nature experience reduces rumination and subgenual prefrontal cortex activation”. Proceedings of the National Academy of Sciences of the United States of America 28 (2015): 8567-8572.
57. Andersen L., et al. “Nature exposure and its effects on immune system functioning: A systematic review”. International Journal of Environmental Research and Public Health 4 (2021): 1416.
58. Siah CJR., et al. “The effects of forest bathing on psychological well-being: A systematic review and meta-analysis”. International Journal of Mental Health Nursing 4 (2023): 1038-1054.
59. Gonzalez MT., et al. “Therapeutic horticulture in clinical depression: a prospective study of active components”. Journal of Advanced Nursing 9 (2010): 2002-2013.
60. Choi M., et al. “Yeast beta-glucan mediates histone deacetylase 5-induced angiogenesis in vascular endothelial cells”. International Journal of Biological Macromolecules 211 (2022): 556-567.
61. Bezerra LS., et al. “Yeast carboxymethyl-glucan improves endothelial function and inhibits platelet aggregation in spontaneously hypertensive rats”. Food and Function 9 (2022): 5406-5415.
62. https://immy.co/?gad_source=1
63. Bazzi S., et al. “Analysis of the immunomodulatory properties of two heat-killed mycobacterial preparations in a human whole blood model”. Immunobiology12 (2015): 1293-1304.
64. Bazzi S., et al. “Immunomodulatory effects of heat-killed Mycobacterium obuense on human blood dendritic cells”. Innate Immunity 7 (2017): 592-605.
65. Holbrook EM., et al. “Mycobacterium vaccae NCTC 11659, a soil-derived bacterium with stress resilience properties, modulates the proinflammatory effects of LPS in macrophages”. International Journal of Molecular Sciences 6 (2023): 5176.
66. Elia A., et al. “Treatment with IMM-101 induces protective CD8+ T cell responses in clinically relevant models of pancreatic cancer”. Poster.
67. Galdon A., et al. “Defining the immunomodulatory effects of IMM-101: a promising, novel co-therapy for cancer”. Poster presented at Brit Soc Immunol. (2016).
68. Bazzi S., et al. “Defining genome-wide expression and phenotypic contextual cues in macrophages generated by granulocyte/macrophage colony-stimulating factor, macrophage colony-stimulating factor, and heat-killed Mycobacteria”. Frontiers in Immunology 8 (2017): 1253.
69. Dalgleish AG., et al. “Randomised, open-label, phase II study of gemcitabine with and without IMM-101 for advanced pancreatic cancer”. British Journal of Cancer 7 (2016): 789-796.
70. O'Brien ME., et al. “SRL172 (killed Mycobacterium vaccae) in addition to standard chemotherapy improves quality of life without affecting survival, in patients with advanced non-small-cell lung cancer: phase III results”. Annals of Oncology 6 (2004): 906-914.
71. Hug LA., et al. “A new view of the tree of life”. Nature Microbiology 1 (2016): 16048.
72. He X., et al. “Cultivation of a human-associated TM7 phylotype reveals a reduced genome and epibiotic parasitic lifestyle”. Proceedings of the National Academy of Sciences of the United States of America 1 (2015): 244-249.
73. Danczak RE., et al. “Members of the candidate phyla radiation are functionally differentiated by carbon- and nitrogen-cycling capabilities”. Microbiome1 (2017): 112.
74. Starr EP., et al. “Stable isotope informed genome-resolved metagenomics reveals that Saccharibacteria utilize microbially-processed plant-derived carbon”. Microbiome1 (2018): 122.