EC Nutrition

Editorial Volume 12 Issue 1 - 2017

Phytosterols and Phytostanols Effect on Health

Sodeif Azadmard-Damirchi* and Parisa Nasirpour-Tabrizi

Department of Food Science and Technology, Faculty of Agriculture, University of Tabriz, Tabriz, Iran
*Corresponding Author: Sodeif Azadmard-Damirchi, Department of Food Science and Technology, Faculty of Agriculture, University of Tabriz, Tabriz, Iran.
Received: October 25, 2017; Published: November 11, 2017



Phytosterols (PS) are triterpenes with a very similar chemical structure to cholesterol, which stabilize phospholipid bilayers in plant cell membranes [1]. PS can be occurred in saturated form (which is called phytostanols) or in unsaturated form. Human cannot synthesize them, therefore, the PS are available orally from vegetables, plant oils, plant extracts, or plant origin supplements such as vegetable oils, nuts, seeds, grain products, fruits and vegetables [2]. The intake of naturally occurring PS from the general diet is about 200 - 400 mg/d [3], and the daily intake of phytostanols is about 30 - 50 mg/day [4].

  • RA Moreau., et al. “Phytosterols, phytostanols, and their conjugates in foods: structural diversity, quantitative analysis, and healthpromoting uses”. Progress in Lipid Research6 (2002): 457-500.
  • J Yi., et al. “Inhibition of cholesterol transport in an intestine cell model by pine-derived phytosterols”. Chemistry and Physics of Lipids 200 (2016): 62-73.
  • RT Ras., et al. “LDL-cholesterol-lowering effect of plant sterols and stanols across different dose ranges: a meta-analysis of randomised controlled studies”. British Journal of Nutrition 2 (2014): 214-219.
  • C Shortt. “Foods, Nutrients and Food Ingredients with Authorised EU Health Claims” (2015): 31.
  • S Azadmard-Damirchi. “Review of the use of phytosterols as a detection tool for adulteration of olive oil with hazelnut oil”. Food Additives and Contaminants 1 (2010): 1-10.
  • E Hovenkamp., et al. “Biological effects of oxidized phytosterols: A review of the current knowledge”. Progress in Lipid Research 1 (2008): 37-49.
  • MH Moghadasian., et al. “Combination effects of wild rice and phytosterols on prevention of atherosclerosis in LDL receptor knockout mice”. The Journal of Nutritional Biochemistry 33 (2016): 128-135.
  • I Wester. “Cholesterol-lowering effect of plant sterols”. European Journal of Lipid Science and Technology 102 (2000): 37-44.
  • H Gylling., et al. “Plant sterols and plant stanols in the management of dyslipidaemia and prevention of cardiovascular disease”. Atherosclerosis2 (2014): 346-360.
  • T Vanmierlo., et al. “Plant sterols: Friend or foe in CNS disorders?”. Progress in Lipid Research 58 (2015): 26-39.
  • ED Smet., et al. “Effects of plant sterols and stanols on intestinal cholesterol metabolism: Suggested mechanisms from past to present”. Molecular Nutrition and Food Research 7 (2012): 1058-1072.
  • JJ Ferguson., et al. “Fat type in phytosterol products influence their cholesterol-lowering potential: A systematic review and metaanalysis of RCTs”. Progress in Lipid Research 64 (2016): 16-29.
  • PG Bradford and AB Awad. “Phytosterols as anticancer compounds”. Molecular Nutrition and Food Research2 (2007): 161-170.
  • T Woyengo., et al. “Anticancer effects of phytosterols”. European Journal of Clinical Nutrition 7 (2009): 813-820.
  • I Rudkowska. “Plant sterols and stanols for healthy ageing”. Maturitas2 (2010): 158-162.
  • YO Callaghan., et al. “Recent advances in Phytosterol Oxidation Products”. Biochemical and Biophysical Research Communications3 (2014): 786-791.
  • Sodeif Azadmard-Damirchi and Parisa Nasirpour-Tabrizi. “Phytosterols and Phytostanols Effect on Health”. EC Nutrition  11.5 (2017): 01-02.