EC Nutrition

Review Article Volume 3 Issue 1 - 2015

Our Immune System IS What We Eat. A Nutritional Immunology Approach

Gomez LM1*, Mesa C1, Restrepo O1, Duque JC1 and Henao JA1

1Grupo de Investigación Nutri-Solla, Solla S.A. Itagüí-Colombia

*Corresponding Author: Luis-Miguel Gomez Osorio, Investigación y Desarrollo Solla S.A., Carrera 42 No. 33-80 autopista Sur, Itagüí, Antioquia, Colombia.
Received: November 21, 2015; Published: December 29, 2015



Nutritional Immunology combines two fields of knowledge that did not interact to each other a few years ago. Recently, there are a great interest into assess the impact of different kind of foods or part of these, beyond of their nutritional roles. It is well known that this particular interest is related with the impact of food on the immune system either health or illness point of view. According to this, different nutrients such as proteins, carbohydrates, lipids, vitamins and minerals, among others and interact with both innate and adaptive immunity and determine the outcome of a specific challenge. In addition, microbiota is fundamental for the develop- ment and maintenance of the immune system determining its dynamics and composition, and a diet-microbiota-immune system triad is fundamental for people’s development and health. The most important effects of each group of nutrients and its impact on health and disease are reviewed with special emphasizes on human and animal studies.

keywords: Nutritional Immunology; Docosahexaenoic Acid; Eicosapentaenoic Acid; Docosahexaenoic Acid; Microbiota; Food

  1. Beisel WR. “History of nutritional immunology: introduction and overview”. Journal of Nutritionsuppl3 (1992): 591-96.
  2. Crook EM and Hopkins FG. “Further observations on the system ascorbic acid-glutathione-ascorbic acid-oxidase”. Biochemical Journal8 (1938): 1356-1363.
  3. Bower RH. “Nutrition and immune function”. Nutrition in Clinical Practice2 (1990): 189-195.
  4. Li P., et al. “Amino acids and immune function”. British Journal of Nutrition2 (2007): 237-252.
  5. Kipnis J., et al. “Immunity and cognition: what do age-related dementia, HIV-dementia and ‘chemobrain’ have in common?” Trends Immunology10 (2008): 455-463.
  6. Satyaraj E. “Emerging paradigms in immunonutrition”. Topics in Companion Animal Medicine1 (2011): 25-32.
  7. Gore DC., et al. “Influence of fever on the hypermetabolic response in burn-injured children”. Archives of Surgery2 (2003): 169-174.
  8. Hanson DF. “Fever, temperature, and the immune response”. Annals of the New York Academy of Sciences 15 (1997): 453-464.
  9. Newsholme P., et al. “Glutamine and glutamate – their central role in cell metabolism and function”. Cell Biochemistry and Function1 (2003): 1-9.
  10. Newsholme EA and Calder PC. “The proposed role of glutamine in some cells of the immune system and speculative consequences for the whole animal”. Nutrition7-8 (1997: 728-730.
  11. Wu G. “Intestinal mucosal amino acid catabolism”. Journal of Nutrition 8 (1998): 1249-1252.
  12. Wu G and Meininger CJ. “Regulation of nitric oxide synthesis by dietary factors”. Annual Review of Nutrition (2002): 61-86.
  13. Heck TG., et al. “PI:HSP70 expression: does it a novel fatigue signalling factor from immune system to the brain?” Cell Biochemistry and Function3 (2011): 215-226.
  14. Newsholme P and Newsholme EA. “Rates of utilization of glucose, glutamine and oleate and formation of end-products by mouse peritoneal macrophages”. Biochememistry Journal1 (1989): 211-218.
  15. Duval D., et al. “Factors controlling cell proliferation and antibody production in mouse hybridoma cells 1. Influence of the amino acid supply”. Biotechnology and Bioengineering6 (1991): 561-570.
  16. Kudsk KA. “Immunonutrition in surgery and critical care”. Annual Review of Nutrition 26 (2006): 463-479.
  17. Bansal V and Ochoa JB. “Arginine availability, arginase, and the immune response”. Current Opinion in Clinical Nutrition & Metabolic Care2 (2003): 223-228.
  18. Calder PC and Yaqoob P. “Glutamine and the immune system”. Amino Acids3 (1999): 227-241.
  19. Konashi S., et al. “Effects of dietary essential amino acid deficiencies on immunological variables in broiler chickens”. British Journal of Nutrition4 (2000): 449-456.
  20. Abumrad NN and Barbul A. “The use of arginine in clinical practice”. In Metabolic & Therapeutic Aspects of Amino Acids in Clinical Nutrition 2nd ed. (2001): 595-611.
  21. Kim SW., et al. “Functional amino acids and fatty acids for enhancing production performance of sows and piglets”. Asian-Austral-asian Journal of Animal Sciences1 (2003): 295-306.
  22. Sikalidis AK. “Amino acids and immune response: a role for cysteine, glutamine, phenylalanine, tryptophan and arginine in T-cell function and cancer”. Pathology and Oncology Research1 (2014): 9-17.
  23. Yaqoob P. “Fatty acids and the immune system: from basic science to clinical applications”. Proceedings of The Nutrition Society1 (2004): 89-104.
  24. Rees D., et al. “Dose-related effects of eicosapentaenoic acid on innate immune function in healthy humans: a comparison of young and older men”. The American Journal of Clinical Nutrition2 (2006): 331-342.
  25. Faber J., et al. “Supplementation with a fish oil-enriched, high-protein medical food leads to rapid incorporation of EPA into white blood cells and modulates immune responses within one week in healthy men and women”. Journal of Nutrition5 (2011): 964-970.
  26. Von Schacky C., et al. “N-3 fatty acids and cysteinyl-leukotriene formation in humans in vitro, ex vivo and in vivo”. The Journal of Laboratory and Clinical Medicine2 (1993): 302-309.
  27. Calder PC. “N-3 fatty acids, inflammation and immunity: new insights to explain old actions”. Proceedings of the Nutrition Society3 (2013): 326-336.
  28. Bagga D., et al. “Differential effects of prostaglandin derived from w-6 and w-3 polyunsaturated fatty acids on COX-2 expression and IL-6 secretion”. Proceedings of the National Academy of Sciences4 (2003): 1751-1756.
  29. Rojas W., et al. “Inmunologia de Rojas 2015; Editorial CIB 17 edition (spanish)
  30. Mas E., et al. “Resolvins D1, D2, and other mediators of self-limited resolution of inflammation in human blood following n-3 fatty acid supplementation”. Clinical Chemistry10 (2012): 1476-1484.
  31. Serhan CN., et al. “Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators”. Nature Reviews Immunology5 (2005): 349-361.
  32. Sigal LH. “Basic science for the clinician 39: NFkappaB-function, activation, control, and consequences”. Journal of Clinical Rheumatology4 (2006): 207-211.
  33. Lee JY., et al. “Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4”. The Journal of Biological Chemistry20 (2001): 16683-16689.
  34. Pike LJ. “Lipid rafts: bringing order to chaos”. The Journal of Lipid Research4 (2003): 655-667.
  35. Yaqoob P. “The nutritional significance of lipid rafts”. Annual Review of Nutrition2 (2010): 257-282.
  36. Wong SW., et al. “Fatty acids modulate Toll-like receptor 4 activation through regulation of receptor dimerization and recruitment into lipid rafts in a reactive oxygen species-dependent manner”. The Journal of Biological Chemistry40 (2009): 27384-27392.
  37. Korinn ES. “Nutrition and immune function”. Veterinary Clinics of North America2 (2006): 1199-1224.
  38. Van den Berghe G., et al. “Intensive insulin therapy in the critically ill patients”. The New England Journal of Medicine19 (2001): 1359-1367.
  39. McCowen KC., et al. “Hyperglycemia and nutrition support: theory and practice”. Nutrition in Clinical Practice3 (2004): 235-244.
  40. Saker KE., et al. “Monocyte immune cell response and copper status in beef steers grazed on endophyte-infected tall fescue”. Journal of Animal Science10 (1998): 2694-2700.
  41. Lukasewycz OA., et al. “The immune response in copper deficiency. In: Bendich A, Chandra RK, editors. Micronutrients and im- mune functions. Cytokines and metabolism”. New York: The New York Academy of Sciences (1990): 147-159.
  42. Rink L., et al. “Zinc and the immune system”. Proceedings of the Nutrition Society1-2 (2000): 541-552.
  43. Sherman AR. “Influences of iron on immunity and disease resistance. In: Bendich A, Chandra RK, editors. Micronutrients and im- mune functions. Cytokines and metabolism”. New York: The New York Academy of Sciences (1990): 140-146.
  44. Shronts EP. “Basic concepts of immunology and its application to clinical nutrition”. Nutrition in Clinical Practice4 (1993): 177-183.
  45. Huang Z., et al. “The role of selenium in inflammation and immunity: from molecular mechanisms to therapeutic opportunities”. Antioxidants & Redox Signaling7 (2012): 705-743.
  46. Labunskyy VM., et al. “September 15 a thioredoxin-like selenoprotein, is involved in the unfolded protein response and differen- tially regulated by adaptive and acute ER stresses”. Biochemistry35 (2009): 8458-8465.
  47. Hatfield DL and Gladyshev VN. “The outcome of selenium and vitamin E cancer prevention trial (SELECT) reveals the need for better understanding of selenium biology”. Molecular Interval1 (2009): 18-21.
  48. Wu D., et al. “Age-associated changes in immune and inflammatory responses: impact of vitamin E intervention”. Journal of Leu- kocyte Biology4 (2008): 900-914.
  49. Molano A., et al. “Vitamin E, signalosomes and gene expression in T cells”. Molecular Aspects of Medicine1 (2012): 55-62.
  50. Lohmiller JJ., et al. “Aged murine T-lymphocytes are more resistant tooxidative damage due to the predominance of the cells possessing the memory phenotype”. The Journals of Gerontology2 (1996): B132-B140.
  51. Chambial S., et al. “Vitamin C in disease prevention and cure: an overview”. Indian Journal of Clinical Biochemistry4 (2013): 314-328.
  52. Animashaun A., et al. “The effect of zinc and vitamin C supplementation on the immune status of patients with Crohn’s disease”. Clinical Nutrition3 (1990): 137-146.
  53. Haskell BE and Johnston CS. “Complement component C1q activity and ascorbic acid nutriture in guinea pigs”. The American Journal of Clinical Nutrition6 (1991): 1228S–1230S.
  54. Veldhoen M., et al. “Influence of nutrient-derived metabolites on lymphocyte immunity”. Nature Medicine7 (2015): 709-718.
  55. Veldhoen M., et al. “Dietary influences on intestinal immunity”. Nature Reviews Immunology10 (2012): 696-708.
  56. Zeng H and Chi H. “Metabolic control of regulatory T cell development”. Trends Immunology1 (2015): 3-12.
  57. Conley ME., et al. “IgG subclass potential of surface IgM-negative and surface IgM-positive human peripheral blood B cells”. Clinical Immunology and Immunopathology2 (1987): 211-222.
  58. Eckburg PB., et al. “Diversity of the human intestinal microbial flora”. Science 308.5728 (2005): 1635-1638.
  59. Greco DS. “Pediatric Nutrition”. Veterinary Clinics of North America4 (2014): 265-273.
  60. Rathe M., et al. “Clinical applications of bovine colostrum therapy: a systematic review”. Nutrition Review4 (2014): 237-254.
  61. Biswas P., et al. “Immunomodulatory effects of bovine colostrum in human peripheral blood mononuclear cells”. New Microbiology4 (2007): 447-454.

Gomez LM., et al. “Our Immune System IS What We Eat. A Nutritional Immunology Approach”. EC Nutrition  3.1 (2015): 546-556.