For the last 3 decades it has become clear that over-production of free radicals leading to oxidative stress and redox disbalance is involved in the development of different human/animal diseases at various stages of their development. Therefore, during evolution an integrated antioxidant defence network was developed to provide effective protection of biological molecules against damaging effects of reactive oxygen and nitrogen species (RONS) and toxic products of their metabolism. Previously we suggested vitamin E and coenzyme Q to be called “head quarter” of the antioxidant system, while carotenoids, comprising a group of pigments accounting for more than 1000 compounds to be called “communicating services” of the antioxidant defence.
Peter F Surai. "Integrated Antioxidant Defence Network in Animals". EC Nutrition 18.6 (2023): 18-20.
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