EC Nutrition

Research Article Volume 14 Issue 4 - 2019

Effects of Palm Oil Colorant on the Renal Functions and Body Weights of Albino Rats

Oparaocha Evangeline Tochi1*, Akawi Jovita Amarachi1, Eteike Precious2 and Nnodim Johnkennedy3

1Department of Public Health, Federal University of Technoloy, Owerri, Imo State, Nigeria
2Federal Medical Center Owerri, Imo Sate, Nigeria
3Department of Medical laboratory Sciences, Imo State University, Owerri, Nigeria
*Corresponding Author: Oparaocha Evangeline Tochi, Professor, Department of Public Health, School of Health Technology, Federal University of Technology, Owerri, Imo State, Nigeria.
Received: January 10, 2019; Published: March 26, 2019



Background/Objectives: Colorants help in enhancing the aesthetic appeal of food. However, the contents of the colorant could adversely affect the health of consumers. The aim of this study was to investigate the effects of palm oil colorant (Sudan dye) on the renal functions and body weights of the albino rats.

Method: The prospective experimental study was conducted with male albino rats in Owerri, South East Nigeria for a period of 4 weeks. Twenty (20) male albino rats divided into 4 groups (Group I, II, III and IV), each with 5 rats were used. Groups I, II and III were the test group while group IV formed the control group. Groups I, II and III received 50 mg/kg, 100 mg/kg and 150 mg/kg of colorants respectively in addition to the standard feeds and water while Group IV (control group) received only the standard feeds and water for a period of 28 days. Their body weights were measured on days 0, 7, 14, 21 and 28 while serum Urea and Creatinine were measured at the end of study (Day 28). Statistical analysis of the data was done with IBM SPSS version 22.0 using Independent sample T-test.

Results/Discussion: The results showed that the colorant (Sudan dye) induced a significant (P < 0.05) weight gain for rats in groups I and II compared to the control group. There was also a significant (P < 0.05) increase in serum Urea and Creatinine levels when compared with the control and the increase was more at higher doses of the colorant.

Conclusion: Sudan dye used as palm oil colorant has adverse effects on the renal functions and body weight of albino rats and could be harmful to human consumers. This calls for more studies with appropriate enactment and implementation of restrictive laws on the public consumption of palm oil coloured with Sudan dye among populations in Nigeria.

keywords: Palm Oil Colorant; Renal Functions; Body Weight; Adverse Effects; Nigeria

  • Abdellah AD., et al. “Physiological effects of some artificial and natural food colouring on young male albino rats”. Journal of Food Technology Research 2 (2015): 21-32.
  • Naseem Z., et al. “Effects of natural and synthetic dyes on human health”. International Research Journal of Biological Science 10 (2017): 23-29.
  • Otu O. “Adulteration of Crude Palm Oil with Red Dye from the Leaf Sheath of Sorghum Bicolor”. Food Science and Quality Management 17 (2013): 1-7.
  • Mensah AJ. “Assessment of the prevalence of palm oil adulteration with Sudan IV dye in the Greater Accra Region” (2016).
  • Imafidon EK and Okunrobo OL. “Effects of Vernonia amygdalina Del. Extract on Cholesterol level and Lipid Peroxidation status in rats given red dye adulterated palm oil diets”. British Journal of Pharmaceutical Research2 (2012): 98-107.
  • Alamuri GK. “Sudan dyes in foods” (2010).
  • Fonovich TM. “Sudan dyes: are they dangerous for human health?” Journal of Drug and Chemical Toxicology3 (2013): 343-352.
  • International Agency for Research on Cancer (IARC). Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs. Lyon, France: IARC (1987).
  • Cheesbrough M. “District laboratory practice in tropical countries. 2nd edition. Cambridge, UK: Cambridge University Press (2006): 256-352.
  • Ikechukwu GC., et al. “Assessment of sub-chronic effect of two artificial food additives on selected biochemical parameters in wistar rats”. Journal of Pharmacology and Toxicology4 (2017): 180-190.
  • Imafidon EK and Okunrobo OL. “Biochemical evaluation of the effect of Sudan IV dye on liver function”. Journal of Pharmaceutical and Allied Sciences1 (2013): 45-48.
  • Nagy ST., et al. “Adverse effects of some food additives in adult male albino rats”. Current Science International4 (2015): 525-537.
  • Nwanjo HU., et al. “Non-protein nitrogen in blood chemistry: theory, analysis and interpretation”. 1st edition. Owerri, Nigeria: Hacyn publishers (2010): 11-25.
  • Mohamed H., et al. “Toxic effects of some synthetic food colorants and/or flavor additives on male rats”. Toxicology and Industrial Health2 (2012): 224-232.

    • Oparaocha Evangeline Tochi., et al. “Effects of Palm Oil Colorant on the Renal Functions and Body Weights of Albino Rats”. EC Nutrition  14.4 (2019): 311-315.

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