EC Nutrition

Background: The key organ of metabolism is liver. It can be damaged by prolonged use of drugs like paracetamol. Ginger is a commonly used spice which may have hepatoprotective effect.

Objective: To assess effect of ginger on S. ALT and S. ALP paracetamol induced hepatotoxicity.

Methods: This study was carried out at SSMC, Dhaka on 2022. 24 Wister albino male rats were divided into group A (negative control), group B (positive control) and group C (experimental group); 8 rats in each group. Group B received paracetamol (2 g/kg bw/day) for last 3 days. Group C received ginger (400 mg/kg bw/day) for 28 days and paracetamol for last 3 days. Blood was collected for estimation of bilirubin, ALT and ALP at BSMMU. Statistical analysis was done by using SPSS 23. Paired ‘t‘ test, One way ANOVA and post hoc Bonferroni test were done. p value ≤ 0.05 was considered as level of significance.

Result: Mean serum bilirubin, ALT and ALP levels were significantly (p < 0.001) higher in positive control group than negative control. Mean serum bilirubin, ALT and ALP level were non-significantly higher in experimental group than negative control. Moreover, mean serum total bilirubin and ALT levels were significantly (p < 0.001) lower whereas ALP level was non-significantly lower in experimental group than those of positive control group.

Conclusion: The present study reveals that ginger has hepatoprotective effect against paracetamol induced hepatotoxicity in Wister albino male rats.

 Keywords: Hepatotoxicity; Paracetamol; Ginger; Hepatoprotective; Wister Albino Male Rat

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