EC Nutrition

Research Article Volume 19 Issue 2 - 2024

Determinants of Gestational Diabetes Mellitus among Pregnant Women Attending Antenatal Care in Eastern Ethiopia Health Facilities, Ethiopia: A Case Control Study

Zerihun Tariku1*, Bereket Tefera1, Aliya Nure1, Mesfin Kebede1, Dilnesawe Fentie2, Yonatan Solomon3 and Alekaw Sema4

1Public Health Department, Dire Dawa University, College of Medicine and Health Science Dire Dawa, Ethiopia

2Biomedical Department, Dire Dawa University, College of Medicine and Health Science Dire Dawa, Ethiopia

3Nursing Department, Dire Dawa University, College of Medicine and Health Science Dire Dawa, Ethiopia

4Midwifery Department, Dire Dawa University, College of Medicine and Health Science Dire Dawa, Ethiopia

*Corresponding Author: Zerihun Tariku, Public Health Department, Dire Dawa University, College of Medicine and Health Science Dire Dawa, Ethiopia.
Received: December 14, 2023; Published: January 08, 2024



Background and Objective: Gestational diabetes mellitus is neglected threat to mothers and their child. Even though gestational diabetes mellitus is one of the leading non-communicable diseases in Ethiopia, common determining factors that link to it are poorly understood, particularly in the study area. For this reason, identifying common risk factors that have a direct relationship to gaps in gestational diabetes care would be crucial to stop the issue before it arises. To identify factors associated with gestational diabetes mellitus among pregnant women attending antenatal care at public Health facilities in Dire Dawa town 2021.

Materials and Methods: This study was conducted from April 01/04/2021 - May 20/ 05/2021 at four Health Centers and one Hospital in Dire Dawa city. Unmatched case control study was conducted on pregnant women who started ANC follow up. Totally 576 pregnant women which are 144 cases and 432 controls needed for study. Data were entered in to Epi-Data version 3.1 computer software and exported to SPSS statistical software version 22 for analysis. The descriptive analysis was done using numerical summary measures and the data was presented using frequency tables, figures and graphs. All covariates that was significant at p value < 0.25 in bivariate analysis was considered for further multivariable analysis to detect true predictors. To measure the strength of association between variables with pregnant women with gestational diabetes mellitus or without gestational diabetes mellitus, crude and adjusted odd ratios with 95% confidence interval will be calculated. Finally, level of statistical significance was declared at p-value < 0.05.

Results: Maternal age (age > 34) AOR = 4.41; 95% CI: 2.33 - 8.34), family history of diabetes (AOR = 2.56; 95% CI: 1.31 - 4.99), low physical activity (AOR = 2.83; 95% CI: 1.47 - 5.45) and inadequate dietary diversity (AOR =0.35; 95% CI: 0.21 - 0.57) were significantly associated with GDM.

Conclusion and Recommendation(s): Advanced maternal age, family history of diabetes mellitus and occupational status of pregnant women were identified as a risk factors for the occurrence of GDM, while having high physical activity and adequate maternal dietary diversity were revealed to protective factors for GDM. promote blood glucose level testing and strengthen gestational diabetes mellitus screening based on risk factors and putting preventive measures like be Physically active and adequate dietary diversity during pregnancy is helpful to prevent effects of GDM on the mother and newborn. The study’s finding would be an input for decision makers to combat GDM.

 Keywords: Antenatal Ethiopia; Health Facilities; Gestational Diabetes Mellitus; Pregnant Women

  1. Diagnostic criteria and classification of hyperglycaemia first detected in pregnancy. WHO (2013).
  2. Muche AA., et al. “Prevalence of gestational diabetes mellitus and associated factors among women attending antenatal care at Gondar town public health facilities, Northwest Ethiopia”. BMC Pregnancy and Childbirth 19 (2019): 334.
  3. Tang AM., et al. “Determining a global mid-upper arm circumference cutoff to assess malnutrition in pregnant women”. Food and nutrition technical assistance III Project (FANTA) (2016).
  4. Minimum Dietary Diversity for Women: A Guide for Measurement. FANTA (2016).
  5. Edwards MK and Loprinzi PD. “Affective responses to acute bouts of aerobic exercise, mindfulness meditation, and combinations of exercise and meditation”. Psychological Reports2 (2019): 465-484.
  6. Lapolla A., et al. “New IADPSG recommendations: impact on care for gestational diabetes”. Diabetes Management5 (2011): 497-508.
  7. Egbe TO., et al. “Prevalence and risk factors of gestational diabetes mellitus in a population of pregnant women attending three health facilities in Limbe, Cameroon: a cross-sectional study”. Pan African Medical Journal 31 (2018): 195.
  8. Solomon CG., et al. “A prospective study of pregravid determinants of gestational diabetes mellitus”. JAMA13 (1997): 1078-1083.
  9. American Diabetes Association. “Diagnosis and classification of diabetes mellitus”. Diabetes Care 5 (2014): 10.
  10. The American College of Obstetricinas and Gynecologists. Clinical management guidelines for obstetrician-gynacologists. ACOG Practice Bulletin. The American College of Obstetricians and Gynecologists (2017): 180.
  11. Mengesha MM., et al. “Level of physical activity among urban adults and the socio-demographic correlates: A population-based cross-sectional study using the global physical activity questionnaire”. BMC Public Health1 (2019): 1160.
  12. Moshe Hod., et al. The International Federation of Gynecology and Obstetrics (FIGO) Initiative on Gestational Diabetes Mellitus: A pragmatic guide for diagnosis, management, and care”. International Journal of Gynecology and ObstetricsS3 (2015): S173-S211.
  13. Feleke BE. “Determinants of gestational diabetes mellitus, a case-control study”. The Journal of Maternal-Fetal and Neonatal Medicine19 (2018): 2584-2589.
  14. Nguyen CL., et al. “Physical activity during pregnancy is associated with a lower prevalence of gestational diabetes mellitus in Vietnam”. Acta Diabetologica 9 (2018): 955-962.
  15. Wolka E., et al. “Prevalence of gestational diabetes mellitus and associated factors in Southern Ethiopia”. Asian Journal of Medical Sciences1 (2019).
  16. Seyoum B. “Prevalence of gestational diabetes mellitus in rural pregnant mothers in northern Ethiopia”. Diabetes Research and Clinical Practice3 (2019): 247-251.
  17. Kwak SH., et al. “Finding genetic risk factors of gestational diabetes”. Genomics and Informatics4 (2012): 239.
  18. Kaneto H., et al. “Beneficial effects of antioxidants in diabetes: possible protection of pancreatic beta-cells against glucose toxicity”. Diabetes 12 (1999): 2398-2406.
  19. Sue Kirkman M and Schaffner W. “Gestational diabetes mellitus”. Diabetes Care 35 (2012): 941-942.
  20. RyanE A and Enns L. “Role of gestational hormones in the induction of insulin resistance”. Journal of Clinical Endocrinology and Metabolism 2 (1988): 341-347.
  21. Mellitus D and Women P. “Gestational diabetes mellitus in HIV-infected and uninfected pregnant women in Cameroon”. Diabetes Care9 (2013): e141-e143.
  22. Catalano PM., et al. “The hyperglycemia and adverse pregnancy outcome study: Associations of GDM and obesity with pregnancy outcomes”. Diabetes Care4 (2012): 780-786.
  23. Dabelea D. “The predisposition to obesity and diabetes in offspring of diabetic mothers”. Diabetes Care2 (2017): S169-S174.
  24. Seyoum B. “Prevalence of gestational diabetes mellitus in rural pregnant mothers in northern Ethiopia”. Diabetes Research and Clinical Practice3 (1999): 247-251.
  25. Zhu Y., et al. “Prevalence of gestational diabetes and risk of progression to type 2 diabetes: a global perspective”. Current Diabetes Reports 1 (2019): 7.
  26. Ferrara A. “Increasing prevalence of gestational diabetes mellitus: a public health perspective”. Diabetes Care 2 (2007): S141-S146.
  27. Diagnostic criteria and classification of hyperglycemia first detected in pregnancy. Geneva, Switzerland. UN (2013).
  28. Smith and Moore. Diabetes Mellitus and Pregnancy. Medscape drugs, diseases and procedures (2012).
  29. “Gestational diabetes: risks, management, and treatment options”. International Journal of Women's Health 2 (2010): 339-351.
  30. International Diabetes Federation: Diabetes atlas. Brussels, Belgium (2015).
  31. Dempsey JC., et al. “A case-control study of maternal recreational physical activity and risk of gestational diabetes mellitus”. Diabetes Research and Clinical Practice2 (2004): 203-215.
  32. Wakwoya EB., et al. “Gestational diabetes mellitus is a risk for macrosomia: case-control study in eastern Ethiopia”. bioRxiv (2018).
  33. Macaulay S., et al. “The prevalence of gestational diabetes mellitus amongst black South African women is a public health concern”. Diabetes Research and Clinical Practice 139 (2018): 278-287.

Zerihun Tariku., et al., “Determinants of Gestational Diabetes Mellitus among Pregnant Women Attending Antenatal Care in Eastern Ethiopia Health Facilities, Ethiopia: A Case Control Study”. EC Nutrition  19.2 (2024): 01-12.