EC Nutrition

There is a lack of information about nutrition in hematology gene and cellular therapy. The role of nutrition is essential because malnutrition, obesity, and nutrient deficiency are strongly associated with damage to the immune system. A search was conducted on 10 July 2022 using PubMed, comprised of over 33 million citations for biomedical literature from MEDLINE, life science journals, and online books. Databases were screened for search terms in titles and abstracts referring to nutrition, nutrition intervention, gene therapy, Chimeric Antigen Receptor (CAR)-T cell Therapy, and Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR). This report summarizes interventional nutrition studies in oncology and hematology settings and describes possible nutritional interventions to improve gene and cellular therapy outcomes. The impact of nutrition evaluation and intervention needs to be studied prospectively.

Keywords: Nutrition; Genic Therapy; Car-T Cell; Zinc; Vitamin D; Microbiota; Omega 3

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