EC Nutrition

Editorial Volume 17 Issue 7 - 2022

From the Zoo to the Clinic; New Ideas about Cancer

Paul Clayton*

Society of Integrated Medicine, Warsaw, Poland

*Corresponding Author: Paul Clayton, Society of Integrated Medicine, Warsaw, Poland.
Received: June 29, 2022; Published: June 30, 2022




Text: Peto’s Paradox [1], named after the great epidemiologist and statistician Sir Richard Peto, is well known in cancer circles. If every cell has a similar chance of becoming cancerous (due to random DNA hits/mutations), then larger animals with longer life-spans and more cells in their bodies should have higher rates of cancer. The fact that they don’t, is the paradox.

  1. Peto R. “Epidemiology, multistage models, and short-term mutagenicity tests”. Origins of Human Cancer, editions HH Hiatt, JD Watson, JA Winsten (Cold Spring Harbor Laboratory Press, New York) (1977): 1403-1428.
  2. Vincze O., et al. “Cancer risk across mammals”. Nature7892 (2022): 263-267.
  3. Werrimont SM., et al. “Polyphenol-rich Dietary Fiber Sources Increased Antioxidant and Anti-inflammatory Polyphenols in the Lower Gastrointestinal Tracts of Healthy Adult Cats While Maintaining Fecal Characteristics Similar to Control”. FASEB1 (2020): 1-1.
  4. Werrimont SM., et al. “Specialized Dietary Fiber Sources Improved Stool Parameters, Increased Fecal Saccharolytic and Fermentative Metabolites, and Delivered Antioxidant and Antiinflammatory Polyphenols to the Lower Gastrointestinal Tract of Healthy Adult Cats. FASEB 33(S1)”. Experimental Biology 2019 Meeting Abstracts (2019): 587.2-587.2.
  5. Fritsch D and Gross K. Novel Dietary Fiber Blend Alters Metabolism of Gastrointestinal Microbiome to Improve Digestive Health and Produce Beneficial Postbiotics in Adult Cats (2021).
  6. Werrimont SM., et al. Food with Specialized Dietary Fiber Sources Improves Clinical Outcomes in Adult Cats with Constipation or Diarrhea (2020).
  7. Carlson A., et al. “Anticancer effects of resveratrol in canine hemangiosarcoma cell lines”. Veterinary and Comparative Oncology2 (2018): 253-261.
  8. Ding S., et al. “The Protective Effect of Polyphenols for Colorectal Cancer”. Frontiers in Immunology 11 (2020): 1407.
  9. Magrone T., et al. “Administration of a Polyphenol-Enriched Feed to Farmed Sea Bass (Dicentrarchus labrax) Modulates Intestinal and Spleen Immune Responses. Oxid”. Oxidative Medicine and Cellular Longevity (2016): 2827567.
  10. Zhong X., et al. “Polyphenol extracts from Punica granatum and Terminalia chebula are anti-inflammatory and increase the survival rate of chickens challenged with Escherichia coli”. Biological and Pharmaceutical Bulletin 10 (2014): 1575-1582.
  11. Abegglen LM., et al. “Potential Mechanisms for Cancer Resistance in Elephants and Comparative Cellular Response to DNA Damage in Humans”. The Journal of the American Medical Association17 (2015): 1850-1860.
  12. Sulak M., et al. “TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants”. Elife 5 (2016): e11994.
  13. Vazquez JM., et al. “A Zombie LIF Gene in Elephants Is Upregulated by TP53 to Induce Apoptosis in Response to DNA Damage”. Cell Reports7 (2018): 1765-1776.
  14. Gammon C. “Cancer in wildlife May Signal Toxic Dangers”. Scientific American (2009).
  15. Martineau D., et al. “Cancer in wildlife, a case study: beluga from the St. Lawrence estuary, Québec, Canada”. Environmental Health Perspectives3 (2002): 285-292.
  16. Pesavento PA., et al. “Cancer in wildlife: patterns of emergence”. Nature Reviews Cancer10 (2018): 646-661.
  17. NIH National Cancer Institute ‘21.
  18. Cancer Research UK ’21.
  19. Gurven M., et al. “Mortality experience of Tsimane Amerindians of Bolivia: regional variation and temporal trends”. American Journal of Human Biology 19 (2007): 376-398.
  20. Foscolou A., et al. “The Association of Healthy Aging with Multimorbidity: IKARIA Study”. Nutrients4 (2021): 1386.
  21. Buettner D and Skemp S. “Blue Zones: Lessons From the World's Longest Lived”. AJLM - American College of Lifestyle Medicine5 (2016): 318-321.
  22. Clayton P and Rowbotham J. “How the mid-Victorians worked, ate and died”. International Journal of Environmental Research and Public Health3 (2009): 1235-1253.
  23. Islami F., et al. “Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States”. CA: A Cancer Journal for Clinicians1 (2018): 31-54.
  24. Fiolet T., et al. “Consumption of ultra-processed foods and cancer risk: results from Nutri Net-Santé prospective cohort”. British Medical Journal on JSTOR 360 (2018): k322.
  25. Albuquerque TAF., et al. “From humans to hydra: patterns of cancer across the tree of life”. Biological Reviews of the Cambridge Philosophical Society3 (2018): 1715-1734.
  26. Gardner HL., et al. “Dogs as a Model for Cancer”. Annual Review of Animal Biosciences 4 (2016): 199-222.
  27. Pang LY and Argyle DJ. “Veterinary oncology: Biology, big data and precision medicine”. The Veterinary Journal 213 (2016): 38-45.
  28. Merlo DF., et al. “Cancer incidence in pet dogs: findings of the Animal Tumor Registry of Genoa, Italy”. Journal of Veterinary Internal Medicine4 (2008): 976-984.
  29. Delicano RA., et al. “The shared risk of diabetes between dog and cat owners and their pets: register based cohort study”. British Medical Journal on JSTOR 371 (2020): m4337.
  30. Lo CH., et al. “Periodontal disease, tooth loss, and risk of oesophageal and gastric adenocarcinoma: a prospective study”. Gut3 (2021): 620-621.
  31. Thomsen H., et al. “Runs of homozygosity and inbreeding in thyroid cancer”. BMC Cancer 16 (2016): 227.
  32. Feldman JG., et al. “Occurrence of acute leukemia in females in a genetically isolated population”. Cancer 38 (1976): 2548-2550.
  33. Rudan I., et al. “Inbreeding and risk of late onset complex disease”. Journal of Medical Genetics 40 (2003): 925-932.
  34. Thomsen H., et al. “Evidence of inbreeding in Hodgkin lymphoma”. PLoS ONE 11 (2016): e0154259.
  35. Assié G., et al. “Frequency of germline genomic homozygosity associated with cancer cases”. The Journal of the American Medical Association 299 (2008): 1437-1445.
  36. Orloff MS., et al. “Integrative genomic analysis reveals extended germline homozygosity with lung cancer risk in the PLCO cohort”. PLoS ONE 7 (2012): e31975.
  37. Deligezer U., et al. “Homozygosity at the C677T of the MTHFR gene is associated with increased breast cancer risk in the Turkish population”. In Vivo 19 (2005): 889-893.
  38. Lebel RR and Gallagher WB. “Wisconsin consanguinity studies. II. Familial adenocarcinomatosis”. American Journal of Medical Genetics 33 (1989): 1-6.
  39. Wallis C and Holcombe LJ. “A review of the frequency and impact of periodontal disease in dogs”. Journal of Small Animal Practice9 (2020): 529-540.
  40. https://www.youtube.com/watch?v=h1RYRJprFOY
  41. Personal experience. I recommend PlaqueOff, by Pro Den.
  42. Adams VJ., et al. “Methods and mortality results of a health survey of purebred dogs in the UK”. Journal of Small Animal Practice 51 (2010): 512-524.
  43. Dobson JM. “Breed-predispositions to cancer in pedigree dogs”. ISRN Veterinary Science (2013): 941275.
  44. https://www.ozy.com/true-and-stories/i-did-it-6-days-of-eating-dog-food/36846/
  45. https://drpaulclayton.eu/blog/volatile-characters/
  46. Thomas F., et al. “Rare and unique adaptations to cancer in domesticated species: An untapped resource?” Evolutionary Applications Open Access (2020).

Paul Clayton. From the Zoo to the Clinic; New Ideas about Cancer.EC Nutrition 17.7 (2022): 12-17.

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