Mini Review Volume 14 Issue 8 - 2025

Oxidative Stress in Pulmonary Disease: An Underrecognized Target for Therapeutic Intervention Using Natural Glutathione Precursors

Ruben D Restrepo*, Jimmy Gutman and Hugo Palafox

Department of Respiratory Care, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA

*Corresponding Author: Ruben D Restrepo, Department of Respiratory Care, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA. E-mail ID: restrepor@uthscsa.edu
Received: July 08, 2025; Published: July 22, 2025



Oxidative stress is a fundamental yet often overlooked mechanism driving pulmonary injury and chronic inflammation across multiple respiratory diseases, including COPD, asthma, interstitial lung disease, and post-COVID-19 syndromes. Although glutathione (GSH) is the most ubiquitous intracellular antioxidant, strategies to restore GSH through supplementation remain underutilized in clinical practice. Recent data suggest that natural glutathione precursors, such as undenatured cysteine-rich whey protein isolates (CRWPI), may offer a novel, accessible, and safe adjunctive intervention for reducing oxidative stress, improving lung function, and promoting recovery in these populations.

 Keywords: Glutathione; Cysteine; Immunocal; Oxidative Stress; Pulmonary; COVID-19

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Ruben D Restrepo., et al. “Oxidative Stress in Pulmonary Disease: An Underrecognized Target for Therapeutic Intervention Using Natural Glutathione Precursors”. EC Pulmonology and Respiratory Medicine  14.8 (2025): 01-03.