EC Pulmonology and Respiratory Medicine

Lung cancer is one of the most common cancers globally which accounts for a major share of cancer deaths worldwide. Recent GLO- BOCAN report documented that in India, which is the home of over 1.3 billion people, lung cancer is the second most common cause of cancer mortality in males and sixth in females. In India only, the average annual mortality due to lung cancer is more than 60 thousand. There are broadly two categories of human cancers as per the world health organization which include non-small cell lung cancer and small cell lung cancer [1,2].

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2. Majeed R., et al. “Inhibition of phosphotidylinositol-3 kinase pathway by a novel naphthol derivative of betulinic acid induces cell cycle arrest and apoptosis in cancer cells of different origin”. Cell Death and Disease10 (2014): e1459.
3. Aras S and Zaidi MR. “TAMeless traitors: macrophages in cancer progression and metastasis”. British Journal of Cancer11 (2017): 1583-1591.
4. Rayees S., et al. “PAR2-Mediated cAMP Generation Suppresses TRPV4-Dependent Ca2+Signaling in Alveolar Macrophages to Resolve TLR4-Induced Inflammation”. Cell Reports3 (2019): 793-805.e4.
5. Rayees S., et al. “Linking GATA-3 and interleukin-13: implications in asthma”. Inflammation Research4 (2014): 255-265.
6. S Rayees and I Din. “Asthma Heterogeneity-An Update and Challenges”. EC Pulmonology and Respiratory Medicine2 (2020): 1-2.
7. Rayees S., et al. “Acute, sub-acute and general pharmacological evaluation of 5-(3,4-methylenedioxyphenyl)-4-ethyl-2E,4E-penta-dienoic acid piperidide (SK-20): a novel drug bioavailability enhancer”. Environmental Toxicology and Pharmacology2 (2013): 347-359.