EC Pulmonology and Respiratory Medicine

Short Communication Volume 15 Issue 1 - 2026

Sarcoidosis and Alpha-1-Antitrypsin Deficiency: A Perfect (And Undesirable) Storm

C Franciosa*, F Chiaravalloti, C Di Simone, A Esposito, G Lo Muzio, G Piemontese, G Tenaglia and G Zuccarini

P.O. Santo Spirito Pescara, Italy

*Corresponding Author: C Franciosa, P.O. Santo Spirito Pescara, Italy.
Received: October 29, 2025; Published: December 22, 2025



Sarcoidosis and alpha-1-antitrypsin deficiency are two rare systemic diseases frequently leading to chronic pulmonary involvement. Pulmonary involvement is present in 90% of cases of sarcoidosis; the prevalence of this chronic, granulomatous disease is very variable according to geography and race, but an increase in prevalence of around 9% was registered from 1990 to 2020s. Disease burden was particularly important in countries like Italy [1]. Prevalence of alpha-1-antitrypsin deficiency (AATD) is variable too, with a percent in COPD patients until 1.5%, but nowadays this condition is often underdiagnosed. Firstly described in 60s in Swedish population, AATD is a rare genetic disorder caused by mutations in the SERPINA1 gene, which encodes a critical protein involved in protecting lung tissue from damage caused by neutrophil elastase [2].

C Franciosa., et al. “Sarcoidosis and Alpha-1-Antitrypsin Deficiency: A Perfect (And Undesirable) Storm”. EC Pulmonology and Respiratory Medicine  15.1 (2026): 01-03.

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