EC Pulmonology and Respiratory Medicine

Review Article Volume 12 Issue 5 - 2023

Risk Factors Associated with Oropharyngeal Dysphagia in Patients with Lung Transplantation

Zoha Asif1*, Hafeez Punjani1, Afshan Memon1, Ali Punjani2 and Tasneem Ali2

1Audiologist and Speech Language Therapist, College of Speech Language and Hearing Sciences, Faculty Health Sciences, Ziauddin University, Karachi, Pakistan

2Speech Language Therapist, College of Speech Language and Hearing Sciences, Faculty Health Sciences, Ziauddin University, Karachi, Pakistan

*Corresponding Author: Zoha Asif, Audiologist and Speech Language Therapist, College of Speech Language and Hearing Sciences, Faculty Health Sciences, Ziauddin University, Karachi, Pakistan.
Received: April 11, 2023; Published:June 06, 2023



Objective: To identify most prevalent risk factors having greater likelihood of developing oro-pharyngeal dysphagia in patients after the procedure of lung transplantation.

Materials and Methods: 5 databases were searched systematically to select studies for a review. Inclusionary criteria involved studies conducted on patients post lung transplant as their primary surgery, post-operative onset of oropharyngeal dysphagia and laryngeal dysfunction identified in acute settings, original studies available in English.

Result: The analysis of studies shows that there is a greater likelihood of development of oropharyngeal dysphagia in patients after lung transplantation. The most common causes of oropharyngeal dysphagia in patients with lung transplantation include recurrent laryngeal nerve damage, vocal cord palsy, and prolonged endotracheal intubation.

Discussion: The existing articles indicate that signs and symptoms of Oropharyngeal dysphagia are evident in patients after lung transplantation.

Conclusion: Swallow assessment of patients after lung transplantation is crucial due to high incidence of oropharyngeal dysphagia in this population.

Keywords: Oropharyngeal Dysphagia; Risk Factors; Lung Transplantation; Swallow Assessment

  1. Miles Anna., et al. “Dysphagia and medicine regimes in patients following lung transplant surgery: a retrospective review”. International Journal of Speech-Language Pathology4 (2021): 339-348.
  2. Reedy Erin L., et al. “Characterizing Swallowing Impairment in a Post–Lung Transplant Population”. American Journal of Speech-Language Pathology (2023): 1-16.
  3. McIntyre Melanie., et al. “Post-extubation dysphagia incidence in critically ill patients: A systematic review and meta-analysis”. Australian Critical Care1 (2021): 67-75.
  4. Labuschagne Jason John and Niels Hammer. "Intra-operative detection of a left-sided non-recurrent laryngeal nerve during vagus nerve stimulator implantation”. Medicina10 (2020): 489.
  5. Schramm Dirk., et al. “Pediatric airway endoscopy: Recommendations of the Society for Pediatric Pneumology”. Respiration11 (2021): 1128-1145.
  6. Marin Sergio., et al. “Healthcare costs of post‐stroke oropharyngeal dysphagia and its complications: malnutrition and respiratory infections”. European Journal of Neurology11 (2021): 3670-3681.
  7. Xu Zeqin., et al. “Dysphagia and aspiration pneumonia in elderly hospitalization stroke patients: risk factors, cerebral infarction area comparison”. Journal of Back and Musculoskeletal Rehabilitation1 (2019): 85-91.
  8. Van Der Mark., et al. “Developments in lung transplantation over the past decade”. European Respiratory Review157 (2020).
  9. Black Rebecca J., et al. “Swallowing and laryngeal complications in lung and heart transplantation: Etiologies and diagnosis”. The Journal of Heart and Lung Transplantation12 (2021): 1483-1494.
  10. Black Rebecca J., et al. “Clinical predictors for oropharyngeal dysphagia and laryngeal dysfunction after lung and heart transplantation”. International Journal of Language and Communication Disorders6 (2019): 894-901.
  11. Black Rebecca., et al. “Oropharyngeal dysphagia and laryngeal dysfunction after lung and heart transplantation: A systematic review”. Disability and Rehabilitation15 (2020): 2083-2092.
  12. Yildiz Tulin., et al. “Does preoperative sleep quality and distress tolerance levels in cardiovascular surgery patients affect postoperative intensive care processes?”. Journal of Clinical Medicine of Kazakhstan4 (2021): 23-26.
  13. Raciti Loredana., et al. “Neurogenic dysphagia and nutrition in disorder of consciousness: an overview with practical advices on an “old” but still actual clinical problem”. Medicines2 (2022): 16.
  14. Dallal-York Justine., et al. “Incidence, risk factors, and sequelae of dysphagia mediated aspiration following lung transplantation”. The Journal of Heart and Lung Transplantation8 (2022): 1095-1103.
  15. Huh Sungchul., et al. “Clinical impact of preoperative diaphragm dysfunction on early outcomes and ventilation function in lung transplant: a single-center retrospective study”. Journal of Intensive Care1 (2022): 23.
  16. Dziewas Rainer., et al. “Diagnosis and treatment of neurogenic dysphagia–S1 guideline of the German Society of Neurology”. Neurological Research and Practice1 (2021): 1-30.
  17. Scarpel Renata D’Arc., et al. “Oropharyngeal swallowing dynamic findings in people with asthma”. Dysphagia 36 (2021): 541-550.
  18. Thomas Caroline R and Gunchu Randhawa. “The Respiratory System E-Book: Basic science and clinical conditions”. Elsevier Health Sciences (2022).
  19. Stojek Magdalena and Tomasz Jasiński. "Gastroparesis in the intensive care unit”. Anaesthesiology Intensive Therapy5 (2021): 450-455.
  20. Jaime Méndez., et al. “Gastroesophageal Reflux and Respiratory Diseases”. Pediatric Respiratory Diseases: A Comprehensive Textbook (2020): 561-569.
  21. Fessler Julien., et al. “Inhaled nitric oxide dependency at the end of double‐lung transplantation: a boosted propensity score cohort analysis”. Transplant International3 (2019): 244-256.
  22. Saketkoo Lesley Ann., et al. “A comprehensive framework for navigating patient care in systemic sclerosis: A global response to the need for improving the practice of diagnostic and preventive strategies in SSc”. Best Practice and Research Clinical Rheumatology3 (2021): 101707.
  23. Stepien Karolina M., et al. “Non-cardiac manifestations in adult patients with Mucopolysaccharidosis”. Frontiers in Cardiovascular Medicine 9 (2022).
  24. Wadia Rajeev S., et al. "Update on perioperative pediatric pulmonary hypertension management”. Journal of Cardiothoracic and Vascular Anesthesia3 (2022): 667-676.
  25. Hoffmeister Jesse., et al. “Postextubation dysphagia in pediatric populations: incidence, risk factors, and outcomes”. The Journal of Pediatrics 211 (2019): 126-133.
  26. Osbeck Sandblom Hanna., et al. “Characterization of dysphagia and laryngeal findings in COVID-19 patients treated in the ICU-An observational clinical study”. PLoS One6 (2021): e0252347.
  27. Langmore Susan E., et al. “Abnormalities of aspiration and swallowing function in survivors of acute respiratory failure”. Dysphagia 36 (2021): 831-841.
  28. Crespo Maria M., et al. “ISHLT consensus document on lung transplantation in patients with connective tissue disease: Part III: Pharmacology, medical and surgical management of post-transplant extrapulmonary conditions statements”. The Journal of Heart and Lung Transplantation11 (2021): 1279-1300.
  29. Kim Christine M and Karuna Dewan. "Vocal fold paralysis and dysphagia”. Current Otorhinolaryngology Reports 9 (2021): 101-106.
  30. Seeliger Benjamin., et al. “Risk factors and outcomes of vocal cord paralysis after lung transplantation–a retrospective cohort study”. Transplant International6 (2019): 626-634.
  31. Harabuchi Yasuaki., et al. “Clinical characteristics, the diagnostic criteria and management recommendation of otitis media with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (OMAAV) proposed by Japan Otological Society”. Auris Nasus Larynx1 (2021): 2-14.
  32. Verdial Francys C., et al. “Safety and costs of endobronchial ultrasound-guided nodal aspiration and mediastinoscopy”. Chest3 (2020): 686-693.
  33. Murry Thomas., et al. “Clinical management of swallowing disorders”. Plural Publishing (2020).
  34. Plowman EK., et al. “Incidence of Dysphagia and Associated Morbidity in Lung Transplanted Adults”. The Journal of Heart and Lung Transplantation4 (2020): S385.
  35. Baijens Laura WJ., et al. “European white paper: oropharyngeal dysphagia in head and neck cancer”. European Archives of Oto-Rhino-Laryngology 278 (2021): 577-616.
  36. Pomfret Sarah A. “Characterizing oropharyngeal swallowing following single lung transplantation in adults”. Diss. University of Pittsburgh (2016).
  37. Cuenca Alex G., et al. “Pediatric liver transplantation”. Seminars in pediatric surgery”. WB Saunders 26.4 (2017).

Zoha Asif., et al. "Risk Factors Associated with Oropharyngeal Dysphagia in Patients with Lung Transplantation". EC Pulmonology and Respiratory Medicine  12.5 (2023): 01-06.