EC Pulmonology and Respiratory Medicine

Editorial Volume 12 Issue 4 - 2023

Identification of Several Genome-Wide-Associated-Genetic Variants in Critical COVID-19

Attapon Cheepsattayakorn1,2*, Ruangrong Cheepsattayakorn3 and Porntep Siriwanarangsun1

1Faculty of Medicine, Western University, Pathumtani Province, Thailand

210th Zonal Tuberculosis and Chest Disease Center, Chiang Mai, Thailand

3Department of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

*Corresponding Author: Attapon Cheepsattayakorn, 10th Zonal Tuberculosis and Chest Disease Center, Chiang Mai, Thailand.
Received: June 02, 2023; Published:June 14, 2023;




A recent study using genome-wide association study (GWAS), a monocyte transcriptome-wide association study (TWAS) models, and Mendelian randomization revealed association of the critical COPVID-19 with genes related-host factors required for viral replication and entry, immunometabolism, monocyte-macrophage activation and endothelial permeability, and inflammatory signalling; RAB2A and TMPRSS2 (Figure 1) [1], AK5 and SLC2A, PDE4A, and JAK1, respectively [1]. There was critical correlations between predicted gene expression in monocyte [2], blood [3], and lung (Figure 2) [1,4,5].

Attapon Cheepsattayakorn., et al. "Identification of Several Genome-Wide-Associated-Genetic Variants in Critical COVID-19". EC Pulmonology and Respiratory Medicine  12.4 (2023): 65-66.

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