EC Pulmonology and Respiratory Medicine

Case Report Volume 13 Issue 9 - 2024

Case Report on Supporting Identification and Treatment of the Next Patient with Pulmonary Embolism through AI Risk Assessment Early Warning and VTE Clinical Decision Support System

Yijun Xu1, Guoying Gao1, Yan Li2, Andy Liu3, Jennifer Lao4, Fan Sun5 and Weiguo Lao6*

1Pulmonary and Critical Care Medicine Department of The Affiliated Panyu Central Hospital of Guangzhou Medical University, Guangzhou, China

2Sydney Institute of Traditional Chinese Medicine, Haymarket, NSW, Australia

3Douglass Hanly Moir Pathology, NSW, Australia

4The University of Sydney, NSW, Australia

5Guangdong Intelligent Artificial Intelligence Application Research Institute Co., Ltd., China

6School of Life Sciences, University of Technology Sydney, Ultimo, NSW, Australia

*Corresponding Author: Yijun Xu, Pulmonary and Critical Care Medicine Department of The Affiliated Panyu Central Hospital of Guangzhou Medical University, Guangzhou, China.
Received: April 24, 2024; Published:May 20, 2024



Venous thromboembolism (VTE) is a grave medical condition comprising deep vein thrombosis (DVT) and pulmonary embolism (PE), both of which pose significant threats to patient health and wellbeing. While DVT primarily affects deep veins, particularly in the lower limbs, PE arises when a blood clot dislodges and travels to the pulmonary artery, potentially leading to fatal consequences. The clinical ramifications of VTE are profound, as it ranks among the leading causes of mortality and morbidity worldwide. PE, a severe complication of VTE, manifests with symptoms such as dyspnea, chest pain and haemoptysis, often resulting in life-threatening situations. Conversely, DVT can lead to chronic pain, swelling and even limb dysfunction in severe cases. Given the gravity of VTE, timely diagnosis and prevention are paramount. Consequently, the exploration of early warning systems and clinical decision support mechanisms for VTE holds immense significance in enhancing patient survival rates and mitigating associated complications. In this context, our critical care department, with support from the Science and Technology Bureau, has developed a VTE clinical decision support system leveraging Artificial Intelligence (AI). The system, currently in the testing phase, aims to provide a secure and reliable platform for early diagnosis and treatment decision-making. By harnessing AI technology, we endeavour to improve the accuracy of VTE risk assessment and streamline clinical management protocols, ultimately advancing patient outcomes. The most important part of this system is to input standardized VTE patients, and this case report is one of the standardized patients that is selected and input for the system to automatically recognize and learn.

 Keywords: Venous Thromboembolism (VTE); Deep Vein Thrombosis (DVT); Pulmonary Embolism (PE); Artificial Intelligence (AI)

  1. Duffett L. “Deep venous thrombosis”. Annals of Internal Medicine 9 (2022): ITC129-ITC144.
  2. Berning BJ., et al. “Impact of chemoprophylaxis on thromboembolism following operative fixation of pelvic fractures”. American Surgeon 1 (2022): 126-132.
  3. Chiasakul T., et al. “Artificial intelligence in the prediction of venous thromboembolism: A systematic review and pooled analysis”. European Journal of Haematology 6 (2023): 951-962.
  4. Lam BD., et al. “Artificial intelligence for venous thromboembolism prophylaxis: Clinician perspectives”. Research and Practice in Thrombosis and Haemostasis 8 (2023): 102272.
  5. Maughan BC., et al. “Venous thromboembolism during pregnancy and the postpartum period: risk factors, diagnostic testing, and treatment”. Obstetrical and Gynecological Survey 7 (2022): 433-444.
  6. Wang KL., et al. “The diagnosis and treatment of venous thromboembolism in Asian patients”. Thrombosis Journal 16 (2018): 4.
  7. Opitz I and Ulrich S. “Pulmonary hypertension in chronic obstructive pulmonary disease and emphysema patients: prevalence, therapeutic options and pulmonary circulatory effects of lung volume reduction surgery”. Journal of Thoracic Disease 23 (2018): S2763-S2774.
  8. Zuo W., et al. “Meta-analysis of pulmonary artery denervation for treatment of pulmonary hypertension”. Brazilian Journal of Cardiovascular Surgery 4 (2022): 554-565.
  9. Luger TJ., et al. “Mode of anesthesia, mortality and outcome in geriatric patients”. Zeitschrift für Gerontologie und Geriatrie 2 (2014): 110-124.
  10. Thibodeau JT and Drazner MH. “The role of the clinical examination in patients with heart failure”. JACC: Heart Failure 7 (2018): 543-551.
  11. Kennedy MK., et al. “Balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension: a systematic review and meta-analysis”. CardioVascular and Interventional Radiology 1 (2023): 5-18.
  12. Barnes PJ. “Inflammatory mechanisms in patients with chronic obstructive pulmonary disease”. Journal of Allergy and Clinical Immunology 1 (2016): 16-27.
  13. Dunham-Snary KJ., et al. “Hypoxic pulmonary vasoconstriction: From molecular mechanisms to medicine”. Chest1 (2017): 181-192.
  14. Gibson NS., et al. “Further validation and simplification of the wells clinical decision rule in pulmonary embolism”. Thrombosis and Haemostasis 1 (2008): 229-234.
  15. Konstantinides S and Torbicki A. “Management of venous thrombo-embolism: an update”. European Heart Journal 41 (2014): 2855-2863.
  16. Martinez Licha CR., et al. “Current management of acute pulmonary embolism”. Annals of Thoracic and Cardiovascular Surgery 2 (2020): 65-71.
  17. Khandait H., et al. “Acute pulmonary embolism: Diagnosis and management”. Indian Heart Journal 5 (2023): 335-342.
  18. Sun X., et al. “The outcomes of interventional treatment for Budd-Chiari Syndrome complicated by inferior vena cava thrombosis: Systematic review and meta-analysis”. Gastroenterology and Hepatology 6 (2021): 405-417.
  19. Kato Y., et al. “Anticoagulation therapy for prevention of acute pulmonary thromboembolism in patients with intracerebral hemorrhage in acute phase”. No Shinkei Geka2 (2019): 199-204.
  20. “Antithrombotic drugs and ischaemic stroke”. Prescrire International 143 (2013): 270-271.
  21. Ryan L., et al. “A machine learning approach to predict deep venous thrombosis among hospitalized patients”. Clinical and Applied Thrombosis/Hemostasis (2021): 1076029621991185.
  22. Baron SJ., et al. “Trends in percutaneous device use for the treatment of venous thromboembolism over time in the PINC AI healthcare database and the national inpatient sample”. American Journal of Cardiology (2024).

Yijun Xu., et al. "Case Report on Supporting Identification and Treatment of the Next Patient with Pulmonary Embolism through AI Risk Assessment Early Warning and VTE Clinical Decision Support System ". EC Pulmonology and Respiratory Medicine  13.9 (2024): 01-16.