EC Psychology And Psychiatry

Review Article Volume 12 Issue 5 - 2023

Savant Syndrome: A Concise Review of the Causes, Symptoms, Diagnosis, and Treatment

Dabeluchi C Ngwu1,2†, Nicholas A Kerna3,4†*, John V Flores5, Kevin D Pruitt6,7, ND Victor Carsrud8, Hilary M Holets5, Sudeep Chawla9, Joseph Anderson II10, Abimbola E Arisoyin11, Uchechukwu C Okoye12 and Damilola A Adeyemo13

1Cardiovascular and Thoracic Surgery Unit, Department of Surgery, Federal Medical Center, Umuahia, Nigeria

2Earthwide Surgical Missions, Nigeria

3Independent Global Medical Researchers Consortium

4First InterHealth Group, Thailand

5Orange Partners Surgicenter, USA

6Kemet Medical Consultants, USA

7PBJ Medical Associates, LLC, USA

8Lakeline Wellness Center, USA

9Chawla Health & Research, USA

10International Institute of Original Medicine, USA

11College of Medicine, University of Lagos, Nigeria

12Lincolnshire Partnership NHS Foundation Trust, United Kingdom

13Department of Liberal Arts, Texas A & M University. Corpus Christi, USA

*Corresponding Author: Nicholas A Kerna, (mailing address) POB47 Phatphong, Suriwongse Road, Bangkok, Thailand 10500. Contact: medpublab+drkerna@gmail.com † indicates co-first author
Received: March 27, 2023; Published:April 18, 2023



Savant syndrome (SS) is a unique and rare condition in which individuals with developmental concerns, such as autism or central nervous system (CNS) diseases or illnesses, demonstrate exceptional 'islands of genius' that stand in a striking juxtaposition to overall limitations. These characteristics mean that these individuals exhibit special abilities in some areas. Special skills may often be in music, art, calendar calculations, arithmetic, or mechanical/visual/spatial capabilities. SS can be congenital (present from birth through infancy) or acquired following a brain injury or CNS dysfunction. Typically, it is associated with severe brain metabolic abnormalities, resulting in significant brain network alterations. These alterations are frequently explained by the 'tyranny of the left hemisphere' hypothesis, which states that the left hemisphere is suppressed for the right hemisphere to acquire savant abilities. Neuromodulatory procedures such as transcranial magnetic and direct current stimulation can briefly replicate these brain alterations. These approaches can help discover the potential of 'hidden talent by regulating the metabolism of the brain network. This review explores, summarizes, and discloses the historical and contemporary definition and understanding of SS and its association with autism spectrum disorder and other possible conditions.

Keywords: Autism; Brain Metabolic Abnormalities; CNS Diseases; Neuromodulatory Procedures; Special Abilities

  1. Hiles D. “Savant Syndrome”. Archive (2023). https://web.archive.org/web/20121025162925/http://www.psy.dmu.ac.uk/drhiles/Savant%20Syndrome.htm
  2. Treffert DA. “The savant syndrome: an extraordinary condition. A synopsis: past, present, future”. Philosophical Transactions of the Royal Society B: Biological Sciences1522 (2009): 1351-1357. https://pubmed.ncbi.nlm.nih.gov/19528017/
  3. Foerstl J. “Early interest in the idiot savant”. American Journal of Psychology4 (1989): 566. https://pubmed.ncbi.nlm.nih.gov/2648868/
  4. Scripture EW. “Arithmetical prodigies”. American Journal of Psychology1 (1891): 1. https://www.jstor.org/stable/pdf/1411838.pdf
  5. Treffert DA. “Savant syndrome: realities, myths and misconceptions”. Journal of Autism and Developmental Disorders3 (2014): 564-571. https://scottbarrykaufman.com/wp-content/uploads/2014/02/Savant-Syndrome-Realities-and-Myths.pdf
  6. Treffert DA and Wallace GL. “Islands of genius”. Scientific American6 (2002): 76-85. https://www.scientificamerican.com/article/islands-of-genius-2002-06/
  7. Hughes JR. “A review of Savant Syndrome and its possible relationship to epilepsy”. Epilepsy and Behavior2 (2010): 147-152. https://pubmed.ncbi.nlm.nih.gov/20075011/
  8. Gyarmathy É. “The savant syndrome and its connection to talent development”. Open Science Journal of Psychology2 (2018): 9-16. https://www.researchgate.net/publication/348248663_The_savant_syndrome_and_its_connection_to_talent_development
  9. Happé F and Wallace GL. “Savant Syndrome”. In: Encyclopedia of Human Behavior. Elsevier (2012): 281-285. https://en.wikipedia.org/wiki/Savant_syndrome
  10. Volkmar FR. “Encyclopedia of Autism Spectrum Disorders”. Springer International Publishing (2021). https://link.springer.com/referencework/10.1007/978-1-4419-1698-3
  11. Syndrome-Theories S and Darius EFH. “Running head: SAVANT SYNDROME – THEORIES AND EMPIRICAL FINDINGS”. Diva-portal (2023). https://www.diva-portal.org/smash/get/diva2:2901/FULLTEXT01.pdf
  12. Treffert DA and Ries HJ. “The sudden savant: A new form of extraordinary abilities”. World Medical Journal – WMA1 (2021): 69-73. https://wmjonline.org/wp-content/uploads/2021/120/1/treffert.pdf
  13. Gururangan K. “Acquired savantism: the genesis of accidental genius”. Biological Sciences2 (2011). https://escholarship.org/uc/item/8nt665v8
  14. Diseases Dic. “Savant syndrome- definition, causes and treatment”. Diseases Treatments Dictionary (2023). https://www.britannica.com/science/savant-syndrome
  15. Treffert DA. “Islands of Genius: The Bountiful Mind of The Autistic, Acquired, and Sudden Savant”. Jessica Kingsley Publishers Ltd (2011).
  16. Hermelin B and Connor O. “Talents and preoccupations in idiot-savants”. Psychological Medicine 21 (1991): 959-964. https://pubmed.ncbi.nlm.nih.gov/1780408/
  17. O'Connor N and Hermelin B. “The memory structure of autistic idiot‐savant mnemonists”. British Journal of Psychology1 (1989): 97-111. https://pubmed.ncbi.nlm.nih.gov/2924090/
  18. Pring L. “Memory characteristics in individuals with savant skills”. In: Boucher J, Bowler D, editions. Memory in Autism. Cambridge University Press (2008): 210-230. https://psycnet.apa.org/record/2008-10944-011
  19. Baron-Cohen S., et al. “Talent in autism: hyper-systemizing, hyper-attention to detail and sensory hypersensitivity”. Philosophical Transactions of the Royal Society B - Journals1522 (2009): 1377-1383. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2677592/
  20. Mottron L., et al. “Enhanced perception in savant syndrome: patterns, structure and creativity”. Philosophical Transactions of the Royal Society B - Journals1522 (2009): 1385-1391. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2677591/
  21. Snyder A. “Explaining and inducing savant skills: privileged access to the lower level, less-processed information”. Philosophical Transactions of the Royal Society B - Journals1522 (2009): 1399-1405. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2677578/
  22. Rubenstein JLR and Merzenich MM. “Model of autism: increased ratio of excitation/inhibition in key neural systems: Model of autism”. Genes, Brain and Behavior5 (2003): 255-267. https://www.nature.com/articles/s41598-020-65500-4
  23. Zubrzycki K. “Advanced proficiency and exceptional ability in second languages”. ITL - International Journal of Applied Linguistics1 (2019): 144-149. https://www.degruyter.com/document/doi/10.1515/9781614515173/html?lang=en
  24. Treffert DA and Rebedew DL. “The savant syndrome registry: a preliminary report”. World Medical Journal4 (2015): 158-162. https://pubmed.ncbi.nlm.nih.gov/26436185/
  25. Kandola A. “Savant syndrome: what it is, symptoms, and links to autism”. Medicalnewstoday (2023). https://www.medicalnewstoday.com/articles/savant-syndrome
  26. O'Connor N and Hermelin B. “Low intelligence and special abilities”. Journal of Child Psychology and Psychiatry4 (1988): 391-396. https://pubmed.ncbi.nlm.nih.gov/3063716/
  27. Miller LK. “Defining the savant syndrome”. The Journal of Developmental and Physical Disabilities1 (1998): 73-85. https://link.springer.com/article/10.1023/A:1022813601762
  28. Howlin P., et al. “Savant skills in autism: psychometric approaches and parental reports”. Philosophical Transactions of the Royal Society B - Journals1522 (2009): 1359-1367. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2677586/
  29. Bolte S. “Comparing the intelligence profiles of savant and nonsavant individuals with autistic disorder”. Intelligence2 (2004): 121-131. https://psycnet.apa.org/record/2004-11991-002
  30. Ben-Itzchak E and Zachor AB. “Are special abilities in autism spectrum disorder associated with a distinct clinical presentation?” Aut Spect Dis 7 (2013): 1122-1128. https://www.sciencedirect.com/science/article/abs/pii/S1750946713000962
  31. Enriquez-Barreto L and Morales M. “The PI3K signaling pathway as a pharmacological target in autism related disorders and schizophrenia”. Molecular and Cellular Therapies1 (2016): 2. https://pubmed.ncbi.nlm.nih.gov/26877878/
  32. Daniel E and Menashe I. “Exploring the familial role of social responsiveness differences between savant and non-savant children with autism”. Scientific Reports1 (2020): 2255. https://www.nature.com/articles/s41598-020-59209-7
  33. Nurmi EL., et al. “Exploratory subsetting of autism families based on savant skills improves evidence of genetic linkage to 15q11-q13”. Journal of the American Academy of Child and Adolescent Psychiatry7 (2003): 856-863. https://pubmed.ncbi.nlm.nih.gov/12819446/
  34. Ma DQ., et al. “Ordered-subset analysis of savant skills in autism for 15q11-q13”. American Journal of Medical Genetics, Part B, Neuropsychiatric Genetics1 (2005): 38-41. https://pubmed.ncbi.nlm.nih.gov/15756693/
  35. Steffenburg S., et al. “A twin study of autism in Denmark, Finland, Iceland, Norway and Sweden”. Journal of Child Psychology and Psychiatry3 (1989): 405-416. https://pubmed.ncbi.nlm.nih.gov/2745591/
  36. Bailey A., et al. “Autism as a strongly genetic disorder: evidence from a British twin study”. Psychological Medicine1 (1995): 63-77. https://pubmed.ncbi.nlm.nih.gov/7792363/
  37. Bailey A., et al. “Autism: towards an integration of clinical, genetic, neuropsychological, and neurobiological perspectives”. Journal of Child Psychology and Psychiatry1 (1996): 89-126. https://pubmed.ncbi.nlm.nih.gov/8655659/
  38. Vital PM., et al. “Relationship between special abilities and autistic-like traits in a large population-based sample of 8-year-olds”. Journal of Child Psychology and Psychiatry9 (2009): 1093-1101. https://pubmed.ncbi.nlm.nih.gov/19490312/
  39. Young RR. “Savant Syndrome: Processes Underlying Extraordinary Abilities/Robyn Young (Doctoral Dissertation)”. Edu (2023). https://digital.library.adelaide.edu.au/dspace/handle/2440/18543
  40. Hill AL. “Idiot savants: rate of incidence”. Percept Mot Skills1 (1977): 161-162. https://journals.sagepub.com/doi/10.2466/pms.1977.44.1.161
  41. Saloviita T., et al. “Incidence of savant syndrome in Finland”. Percept Mot Skills1 (2000): 120-122. https://pubmed.ncbi.nlm.nih.gov/11011882/
  42. Heaton P and Wallace GL. “Annotation: the savant syndrome”. Journal of Child Psychology and Psychiatry5 (2004): 899-911. https://acamh.onlinelibrary.wiley.com/doi/abs/10.1111/j.1469-7610.2004.t01-1-00284.x
  43. Muhammad K. “Management of Savant Syndrome”. Iiardjournals. Org (2023).
  44. Selfe L. “A Single Case Study of an Autistic Child with Exceptional Drawing Ability”. In: The Child's Representation of the World (1977): 31-48. https://link.springer.com/chapter/10.1007/978-1-4684-2349-5_2
  45. O'Connor N and Hermelin B. “Visual memory and motor programmes: their use by idiot-savant artists and controls”. British Journal of Psychology3 (1987): 307-323. https://pubmed.ncbi.nlm.nih.gov/3620791/
  46. Jeon Y. “Savant syndrome: a review of research findings”. Stcloudstate (2023). https://repository.stcloudstate.edu/cgi/viewcontent.cgi?referer=&httpsredir=1&article=1025&context=sped_etds
  47. Dubischar-Krivec AM., et al. “Calendar calculating in savants with autism and healthy calendar calculators”. Psychological Medicine 39 (2009): 1355-1363. https://pubmed.ncbi.nlm.nih.gov/18940023/
  48. Thioux M., et al. “The day of the week when you were born in 700 ms: calendar computation in an Autistic savant”. Journal of Experimental Psychology: Human Perception and Performance5 (2006): 1155-1168. https://www.researchgate.net/publication/6791131_The_day_of_the_week_when_you_were_born_in_700_ms_Calendar_computation_in_an_Autistic_savant
  49. Ho ED., et al. “An investigation of the calendar calculation ability of a Chinese-calendar savant”. Journal of Autism and Developmental Disorders 1991;21 (1991): 315-327. https://link.springer.com/article/10.1007/BF02207328
  50. Kumar L. 7 amazing and famous people with savant syndrome (2023). https://wecapable.com/famous-autistic-savants/
  51. 10 most fascinating savants in the world. Neatorama (2023). https://www.neatorama.com/2008/09/05/10-most-fascinating-savants-in-the-world/
  52. Frater J. “10 fascinating people with savant syndrome”. Listverse (2023). https://listverse.com/2013/07/23/10-fascinating-people-with-savant-syndrome/
  53. Snyder A., et al. “Savant-like numerosity skills revealed in normal people by magnetic pulses”. Perception6 (2006): 837-845. https://pubmed.ncbi.nlm.nih.gov/16836048/
  54. Snyder AW and Mitchell DJ. “Is integer arithmetic fundamental to mental processing? The mind's secret arithmetic”. Proceedings of the Royal Society B: Biological Sciences1419 (1999): 587-592. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1689812/
  55. Snyder AW., et al. “Savant-like skills exposed in normal people by suppressing the left fronto-temporal lobe”. Journal of Integrative Neuroscience02 (2003): 149-158.
  56. Young RL., et al. “Switching skills on by turning off part of the brain”. Neurocase3 (2004): 215-222. https://pubmed.ncbi.nlm.nih.gov/15788259/
  57. Birbaumer N. “Neurobiology. Rain man's revelations: neurobiology”. Nature6733 (1999): 211-212. https://pubmed.ncbi.nlm.nih.gov/10353240/
  58. Sacks O. “The mind's eye”. New Yorker (1925). https://www.oliversacks.com/oliver-sacks-books/the-minds-eye/
  59. Humphrey N. “Shamanism and cognitive evolution”. Cambridge Archaeology Journal (2002): 12. https://www.researchgate.net/publication/231979846_Shamanism_and_cognitive_evolution
  60. Quka AA. “Savant syndrome - causes”. Icliniq (2023). https://www.icliniq.com/articles/neurological-health/savant-syndrome
  61. Kathleen Davis FNP. “Cognitive behavioral therapy: How does CBT work?” Medicalnewstoday (2023). https://www.medicalnewstoday.com/articles/296579
  62. Scarpa A., et al. “CBT for Children and Adolescents with High-Functioning Autism Spectrum Disorders. Guilford Press (2013). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357340/
  63. King W. “Autism Spectrum Disorder”. Lumenlearning (2023). https://www.nimh.nih.gov/health/topics/autism-spectrum-disorders-asd
  64. Encyclopedia (2023). https://encyclopedia.pub/entry/27789
  65. Eikeseth S. “Outcome of comprehensive psycho-educational interventions for young children with autism”. Research In Developmental Disabilities1 (2009): 158-178. https://pubmed.ncbi.nlm.nih.gov/18385012/
  66. Autism and Complementary Alternative Medicine (CAM). Association for Science in Autism Treatment (2023). https://asatonline.org/for-parents/becoming-a-savvy-consumer/complementary-alternative-medicine/
  67. Bent S and Hendren RL. “Complementary and alternative treatments for autism part 1: evidence-supported treatments”. AMA Journal of Ethics4 (2015): 369-374. https://journalofethics.ama-assn.org/article/complementary-and-alternative-treatments-autism-part-1-evidence-supported-treatments/2015-04
  68. Busuttil J. Treating a case of savant syndrome (2023). https://jewelautismcentre.com/jewel_blog/savant-syndroment/
  69. Savant Syndrome. “Benefits of Mainstream and Alternative Education Margo Douglas”. Sacredheart (2023). https://digitalcommons.sacredheart.edu/cgi/viewcontent.cgi?article=1331&context=acadfest

Ngwu DC, Kerna NA, Flores JV, Pruitt KD, Carsrud NDV, Holets HM, Chawla S, Anderson II J, Arisoyin AE, Okoye UC, Adeyemo DA. "Savant Syndrome: A Concise Review of the Causes, Symptoms, Diagnosis, and Treatment". EC Psychology and Psychiatry  12.5 (2023): 33-47.