EC Psychology And Psychiatry

Research Article Volume 15 Issue 1 - 2026

Modifications on Histone Tails in Psychiatric Disorders

Qiao Mao1#, Zhixiong Luo2#, Zongyang Yu3#, Bin Chen4, Kesheng Wang5, Yuping Cao6, Jiawu Ji7, Fan Wang8, Lingjun Zuo9, Chiang-Shan Li9, Xiaoping Wang10*, Yong Zhang11* and Xingguang Luo9*

1Department of Psychosomatic Medicine, People’s Hospital of Deyang City, Deyang, Sichuan, China

2College of Integrative Medicine, Fujian University of Traditional Medicine, Fuzhou, China

3Department of Pulmonary and Critical Care Medicine, Fuzhou General Hospital of Fujian Medical University, Fuzhou, China

4Shengli Clinical Medical College of Fujian Medical University and Department of Cardiovascular Medicine, Fujian Provincial Hospital, Fuzhou, Fujian, China

5Department of Family and Community Health, School of Nursing, Health Sciences Center, West Virginia University, Morgantown, WV, USA

6Department of psychiatry, China National Clinical Research Center on Mental Disorders (Xiangya), the Second Xiangya Hospital of Central South University, ChangSha, China

7Department of Psychiatry, Fujian Medical University Affiliated Fuzhou Neuropsychiatric Hospital, Fuzhou, Fujian, China

8Beijing Huilongguan Hospital, Peking University Huilongguan Clinical School of Medicine, Beijing, China

9Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA

10Department of Neurology, Shanghai Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China

11Institute of Mental Health, Tianjin Anding Hospital, Mental Health Center of Tianjin Medical University, Tianjin, China

*Corresponding Author: Xiaoping Wang, Department of Neurology, Shanghai Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China and Yong Zhang, Institute of Mental Health, Tianjin Anding Hospital, Mental Health Center of Tianjin Medical University, Tianjin, China and Xingguang Luo, Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Received: March 25, 2025; Published: February 11, 2026



The present study provides a comprehensive introduction to the features of histone tails, including their length, subtypes, nomenclature, biological functions, and regulation, and systematically reviews their roles in psychiatric disorders. A literature search was conducted, covering over 200 common histone modifications and the top 20 common psychiatric disorders. The results indicate that 26 histone tail modifications are positively associated with ten psychiatric disorders, with most located at H3 and H4 tails, and only one at the H2AX tail. All modifications occur at lysines (K), except for two at arginine (R) or serine (S). The top five modifications associated with psychiatric disorders are H3K9ac, H3K4me3, H3K27ac, H3K9me2, and γH2AX. The majority of the studies (92%) report substance use disorders, Alzheimer's disease, major depressive disorder, schizophrenia, and autism spectrum disorders as the top five psychiatric disorders associated with histone tail modifications. In conclusion, histone tail modifications play crucial roles in various psychiatric disorders, and targeting them and associated epigenetic regulators may offer potential therapeutic strategies for treating psychiatric disorders by providing new insights into the molecular mechanisms underlying abnormal gene expression.

 Keywords: Histone Tail; Histone Modification; Psychiatric Disorder; Methylation; Acetylation; Epigenetic Regulation; Gene Expression

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Xiaoping Wang., et al. “Modifications on Histone Tails in Psychiatric Disorders”. EC Psychology And Psychiatry  15.1 (2026): 01-19.

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