EC Psychology And Psychiatry

Research Article Volume 13 Issue 8 - 2024

Methylome-Wide Association Studies of Psychiatric Disorders

Qiao Mao1#, Zhixiong Luo2#, Xiaoping Wang3#, Kesheng Wang4, Zhiren Wang5, Yong Zhang6* and Xingguang Luo7*

1Department of Psychosomatic Medicine, People’s Hospital of Deyang City, Deyang, Sichuan, China
2College of Integrative Medicine, Fujian University of Traditional Medicine, Fuzhou, China
3Department of Neurology, Jiading Branch of Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
4Department of Family and Community Health, School of Nursing, Health Sciences Center, West Virginia University, Morgantown, WV, USA
5Beijing Huilongguan Hospital, Peking University Huilongguan Clinical School of Medicine, Beijing, China
6Institute of Mental Health, Tianjin Anding Hospital, Mental Health Center of Tianjin Medical University, Tianjin, China
7Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
*Corresponding Author: Yong Zhang, Institute of Mental Health, Tianjin Anding Hospital, Mental Health Center of Tianjin Medical University, Tianjin, China and Xingguang Luo, Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Received: June 13, 2024; Published: August 02, 2024



Neuroepigenetics underscores the significance of the methylome in both normal and pathological brain function, influencing neurobiological processes and psychiatric well-being. This study systematically examines methylome-wide association studies (MWAS) across various psychiatric disorders that utilize array-based and sequencing approaches on blood or brain tissue samples. The findings provide valuable insights into the early stages of neuropathogenesis in psychiatric disorders, revealing altered epigenetic mechanisms. The methylome emerges as a pivotal factor in the development and treatment of psychiatric conditions, potentially offering avenues for identifying therapeutic targets and informing treatment strategies.

 Keywords: Methylome-Wide Association Study; Psychiatric Disorders; CpG Island; Microarray; Sequencing

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Yong Zhang and Xingguang Luo., et al. “Methylome-Wide Association Studies of Psychiatric Disorders” ”. EC Psychology and Psychiatry  13.8 (2024): 01-10.

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