EC Psychology and Psychiatry

Research Article Volume 12 Issue 3 - 2023

Association of Lesion Location with Post-Stroke Depression in China: A Systematic Review and Meta-Analysis

Xinqun Luo1, Wenhua Fang1, Jiawu Ji2, Yong Zhang3, Rolando Garcia-Milian4, Zhiren Wang5, Yunlong Tan5, Shibin Wang6, Xiaoping Wang7*, Xiaoyun Guo6,8* and Xingguang Luo5*

1Department of Neurosurgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China

2Department of Psychiatry, Fujian Medical University Affiliated Fuzhou Neuropsychiatric Hospital, Fuzhou, Fujian, China

3Department of Bipolar Disorder, Tianjin Anding Hospital, Tianjin, China

4Bioinformatics Support Program, The Cushing/Whitney Medical Library, Yale University School of Medicine, New Haven, CT, USA

5Beijing Huilongguan Hospital, Peking University Huilongguan Clinical School of Medicine, Beijing, China

6Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, China

7Department of Neurology, Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

8Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA

*Corresponding Author: Xiaoping Wang, Department of Neurology, Jiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China and Xiaoyun Guo, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, China and Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA and Xingguang Luo, Beijing Huilongguan Hospital, Peking University Huilongguan Clinical School of Medicine, Beijing, China.
Received: February 11, 2023; Published: February 22, 2023



Background: Post-stroke depression (PSD) is a mental health condition that can develop after a stroke, with a higher risk of death and negative outcomes. However, limited research has explored how PSD incidence relates to brain locations in Chinese patients. This study aims to fill this gap by examining the link between PSD occurrence and brain lesion location, as well as the type of stroke experienced by the patient.

Methods: We conducted a systematic search in databases to gather post-stroke depression literature published between January 1, 2015 and May 31, 2021. Following this, we performed a meta-analysis using RevMan to analyze the incidence of PSD associated with different brain regions and types of stroke separately.

Results: We analyzed seven studies, with a total of 1604 participants. Our findings indicated that the incidence of PSD was higher when the stroke occurred in the left hemisphere compared to the right hemisphere (RevMan: Z = 8.93, P < 0.001, OR = 2.69, 95% CI: 2.16 - 3.34, fixed model); PSD was more common when the stroke affected the cerebral cortex rather than the subcerebral cortex (RevMan: Z = 3.96, P < 0.001, OR = 2.00, 95% CI: 1.42 - 2.81) and when it affected the anterior cortex compared to the posterior cortex (RevMan: Z = 3.85, P < 0.001, OR = 1.89, 95% CI: 1.37 - 2.62). However, we did not find a significant difference in the occurrence of PSD between ischemic and hemorrhagic strokes (RevMan: Z = 0.62, P = 0.53, OR = 0.02, 95% CI: -0.05 - 0.09).

Conclusion: Our findings revealed a higher likelihood of PSD in the left hemisphere, specifically in the cerebral cortex and anterior region.

Keywords: Lesion Location; Post-Stroke Depression; Cortex; Systematic Review

  1. Robinson RG and Jorge RE. “Post-Stroke Depression: A Review”. American Journal of Psychiatry 3 (2016): 221-231.
  2. Cai W., et al. “Post stroke depression and risk of stroke recurrence and mortality: A systematic review and meta-analysis”. Ageing Research Reviews 50 (2019): 102-109.
  3. Roth M. “The natural history of mental disorder in old age”. Journal of Mental Science 423 (1955): 281-301.
  4. Robinson RG., et al. “Two-year longitudinal study of post-stroke mood disorders: comparison of acute-onset with delayed-onset depression”. American Journal of Psychiatry 10 (1986): 1238-1244.
  5. Parikh RM., et al. “Two-year longitudinal study of post-stroke mood disorders: dynamic changes in correlates of depression at one and two years”. Stroke3 (1987): 579-584.
  6. Folstein MF., et al. “Mood disorder as a specific complication of stroke”. Journal of Neurology, Neurosurgery, and Psychiatry10 (1977): 1018-1020.
  7. Mitchell AJ., et al. “Prevalence and predictors of post-stroke mood disorders: A meta-analysis and meta-regression of depression, anxiety and adjustment disorder”. General Hospital Psychiatry 47 (2017): 48-60.
  8. Wang YJ., et al. “China Stroke Statistics 2019: A Report From the National Center for Healthcare Quality Management in Neurological Diseases, China National Clinical Research Center for Neurological Diseases, the Chinese Stroke Association, National Center for Chronic and Non-communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention and Institute for Global Neuroscience and Stroke Collaborations”. Stroke and Vascular Neurology 3 (2020): 211-239.
  9. Morris PL., et al. “Association of depression with 10-year poststroke mortality”. American Journal of Psychiatry 1 (1993): 124-129.
  10. Douven E., et al. “Imaging Markers of Post-Stroke Depression and Apathy: a Systematic Review and Meta-Analysis”. Neuropsychology Review 3 (2017): 202-219.
  11. Zhao XL and Wang M. “Analysis relationship starting post-stroke depression in patients with cerebral infarction and stroke site”. Chin Cont Med Edu 4 (2016): 99-100.
  12. Ru JJ and Sun MZ. “Post-stroke depression related factors and stroke lesion location”. Special Health21 (2017): 72-73.
  13. Liu Y., et al. “Study on post-stroke depression related factors”. Journal of Hebei Medical University 8 (2015): 931-934.
  14. Zeng XT., et al. “Meta analysis of four of the series 4: observational study quality assessment tools”. Chinese Journal of Evidence-Based Cardiovascular Medicine 6 (2012): 496-500.
  15. Amiri P., et al. “Does motivational interviewing improve the weight management process in adolescents? Protocol for a systematic review and meta-analysis”. Systematic Reviews1 (2018): 178.
  16. Li SH., et al. “The analysis of the relationship between post-stroke depression and the region of brain injury”. Capital Medicine 2 (2016): 28-30.
  17. Wei WX and Shui PB. “Correlation studies on post-stroke depression and cerebral lesion location”. Inner Mongolia Medical Journal 3 (2015): 334-335.
  18. Ding XH., et al. “Post-stroke depression and location of brain lesion”. Wannan Medical College 2 (2015): 125-128.
  19. Yang HH. “Relationship between post-stroke depression and stroke lesion location”. Journal of Hebei Medical University 6 (2015): 734-736.
  20. Tian X. “Relationship with the stroke position, stroke frequency, the number of lesions of depression after stroke”. Medical Forum 2 (2016): 146-148.
  21. Yuan JX., et al. “Supplying artery lesions and early post-stroke depression”. Guangdong Medical Journal 38 (2017): 61-64.
  22. He Y., et al. “Research on multi factors analysis and nursing method in the old patients with post-stroke depression”. J Intern Psych4 (2015): 19-22.
  23. Jiang L., et al. “Brain cell apoptosis after cerebral hypoxia-ischemia in neonatal rat”. National Medical Journal of China 8 (1998): 567-569.
  24. Mulders PC., et al. “Resting-state functional connectivity in major depressive disorder: A review”. Neuroscience and Biobehavioral Reviews 56 (2015): 330-344.
  25. Abdallah CG., et al. “Ketamine Treatment and Global Brain Connectivity in Major Depression”. Neuropsychopharmacology6 (2017): 1210-1219.
  26. Cheng W., et al. “Functional Connectivities in the Brain That Mediate the Association Between Depressive Problems and Sleep Quality”. JAMA Psychiatry10 (2018): 1052-1061.
  27. Cantone M., et al. “Cortical Plasticity in Depression”. ASN Neuro3 (2017): 1759091417711512.
  28. Kucharczyk M., et al. “The reduced level of growth factors in an animal model of depression is accompanied by regulated necrosis in the frontal cortex but not in the hippocampus”. Psychoneuroendocrinology 94 (2018): 121-133.
  29. Gu Z., et al. “MiR-124 suppression in the prefrontal cortex reduces depression-like behavior in mice”. Bioscience Reports 9 (2019): BSR20190186.
  30. Martin DM., et al. “Cognitive enhancing effects of rTMS administered to the prefrontal cortex in patients with depression: A systematic review and meta-analysis of individual task effects”. Depress Anxiety11 (2017): 1029-1039.
  31. Huang WY., et al. “Reviews of depression after stroke lesions”. Chinese Journal of Gerontology 6 (2017): 1554-1556.
  32. Li N., et al. “Brain physiological change nature and the location and the correlation analysis of stroke complicated with depression”. Chinese Journal of Clinical Rational Drug Use 8A (2014): 137-138.
  33. Wang J., et al. “Analysis on related factors of post-stroke depression”. Chongqing Medicine24 (2014): 3165-3167.

Xiaoping Wang., et al. Association of Lesion Location with Post-Stroke Depression in China: A Systematic Review and Meta-Analysis. EC Psychology and Psychiatry 12.3 (2023): 34-45.

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