EC Paediatrics

Research Article Volume 12 Issue 5 - 2023

Short Term Effect of Norepinephrine on Circulatory Parameters, Acidosis and Kidney Function and Survival in Neonates with Severe Hypotension’ and Shock

Nisha Viji Varghese1*, Tasnim Dawoud1, Aiman Rahmani1, Mohammad Khassawneh2 and Mustafa Ali Abdullatif1

1Neonatal Unit, Department of Pediatrics, Tawam Hospital, Alain, UAE
2Department of Pediatrics, Jordan University of Science and Technology, Amman, Jordan

*Corresponding Author: Nisha Viji Varghese, Neonatal Unit, Department of Pediatrics, Tawam Hospital, Alain, UAE.
Received: March 07, 2023; Published: April 18, 2023




Norepinephrine is an endogenous catecholamine that increases systemic vascular resistance (SVR) via the activation of α1 receptors. Cardiac output is increased by activation of cardiac β1 receptors to improve contractility, and α1 mediated venoconstriction to help increase venous return and preload. In view of its predominant α1 activity, Norepinephrine is the preferred vasopressor for the treatment of septic shock in children and adults which is characterised by a low SVR. The clinical literature on norepinephrine use in neonates is predominantly involving refractory shock and demonstrates increased BP, improved oxygenation, and decreased serum lactate within hours of initiation. Our study showed positive effect on urine output and blood pressure, but also a significant rise in lactate levels following the administration of Norepinephrine which could be attributed to the extremely sick nature of these babies.

Keywords: Norepinephrine; Acidosis; Kidney Function; Neonates; Hypotension; Shock

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Nisha Viji Varghese., et al. Short Term Effect of Norepinephrine on Circulatory Parameters, Acidosis and Kidney Function and Survival in Neonates with Severe Hypotension’ and Shock. EC Paediatrics 12.5 (2023):05-14.

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