Case Report Volume 14 Issue 12 - 2025

Severe Hypercalcaemia and Pancreatitis in a 14-Year-Old with Generalised Lymphadenopathy: A Diagnostic Challenge Between Lymphoma and Tuberculosis

JaC Sameer Atala Abdo1*, Khaled Siddiqui2, Mohamed Hammad3 and Jisna Palliyal3

1Clinical Fellow, Department of General Paediatrics, East Lancashire Hospitals NHS Trust, Blackburn, UK

2Senior Paediatrician, East Lancashire Hospitals NHS Trust, Blackburn, UK

3SCF Paediatrics, East Lancashire Hospitals NHS Trust, Blackburn, UK

*Corresponding Author: JaC Sameer Atala Abdo, Department of General Paediatrics, East Lancashire Hospitals NHS Trust, Blackburn, UK.
Received: November 10, 2025; Published: November 20, 2025



Background: Hypercalcaemia is an uncommon finding in children and most often raises suspicion of malignancy. Granulomatous diseases such as tuberculosis (TB) are rare but important alternative causes.

Case Presentation: A 14-year-old boy was referred by his GP for concerns of abdominal pains and vomiting, with weight loss, and anorexia. The child was seen in Paediatric assessment Unit, Examination revealed Pallor, dehydration, hypertension, epigastric tenderness. Investigations done and revealed severe hypercalcaemia, pancreatitis, suppressed parathyroid hormone, and widespread lymphadenopathy. Lymphoma was initially suspected. However, lymph node biopsy demonstrated granulomatous inflammation, a Mantoux test was strongly positive, and there was a history of TB exposure. He was commenced on anti-tuberculous therapy with resolution of symptoms and normalisation of calcium.

Conclusion: Disseminated TB can mimic haematological malignancy in children. Awareness of this presentation is essential, particularly in patients with TB risk factors, to avoid misdiagnosis and unnecessary chemotherapy.

 Keywords: Hypercalcaemia; Tuberculosis; Paediatrics; Pancreatitis; Lymphadenopathy; Case Report

JaC Sameer Atala Abdo., et al. “Severe Hypercalcaemia and Pancreatitis in a 14-Year-Old with Generalised Lymphadenopathy: A Diagnostic Challenge Between Lymphoma and Tuberculosis”. EC Paediatrics  14.12 (2025): 01-04.