EC Paediatrics

Case Report Volume 13 Issue 8 - 2024

Seizure-Like Activity in an Adolescent with Fahr Syndrome

Sara Farran, Farah Al-Bitar and Berrin Ergun-Longmire*

Department of Pediatrics, Western Michigan University Homer Stryker M.D. School of Medicine, Kalamazoo, MI, USA

*Corresponding Author: Berrin Ergun-Longmire, Department of Pediatrics, Western Michigan University Homer Stryker M.D. School of Medicine, Kalamazoo, MI, USA.
Received: July 22, 2024; Published: July 29, 2024



Pseudohypoparathyroidism, characterized by parathyroid hormone (PTH)-resistance or PTH-unresponsiveness at target organs, is associated with Fahr syndrome which is a rare neurological condition characterized by an abnormal basal ganglia calcification. We present a pediatric case of a 15-year-old male who exhibited seizure-like activity due to pseudohypoparathyroidism, ultimately revealing basal ganglia calcification consistent with Fahr's syndrome. This case underscores the complexity of integrating endocrine and neurological considerations in diagnosis and management, emphasizing the need for collaborative care across medical specialties.

 Keywords: Pseudohypoparathyroidism; Fahr Syndrome; Basal Ganglia Calcification; Seizure Like Activity; Hypocalcemia

  1. Perugula Malathi Latha and Steven Lippmann. “Fahr’s disease or Fahr’s syndrome?” Innovations in Clinical Neuroscience7-8 (2016): 45-46.
  2. Rizvi Syed AA., et al. “Fahr Syndrome”. Consultant3609 (2016).
  3. Berrabeh Soumiya., et al. “Hypoparathyroidism and Fahr’s syndrome: A case series”. Cureus6 (2023): e40502.
  4. Lauterbach Edward C., et al. “Neuropsychiatric disorders, myoclonus, and dystonia in calcification of basal ganglia pathways”. Biological Psychiatry5 (1994): 345-351.
  5. Moriwaki Y., et al. “Cerebral subcortical calcification and hypoparathyroidism--a case report and review of the literature”. Japanese Journal of Medicine1 (1985): 53-56.
  6. Lee Yoo Jin., et al. “A case of seizure revealing Fahr’s syndrome with primary hypoparathyroidism”. The American Journal of Case Reports 19 (2018): 1430-1433.
  7. Chevalier D., et al. “Une cause de calcifications intracérébrales à ne pas méconnaître: Le syndrome de Fahr”. Revue de Medecine Interne8 (2005): 668-677.
  8. El Maghraoui A., et al. “Syndrome de Fahr et dysparathyroidie. 3 observations”. Presse Medicale28 (1995): 1301-1304.
  9. Goswami Ravinder., et al. “Prevalence and progression of basal ganglia calcification and its pathogenic mechanism in patients with idiopathic hypoparathyroidism”. Clinical Endocrinology2 (2012): 200-206.
  10. Hernández Maria Del C Valdés., et al. “Identification of mineral deposits in the brain on radiological images: a systematic review”. European Radiology11 (2012): 2371-2381.
  11. Sbai H., et al. “Syndrome de Fahr découvert à la suite d’une méningite à pneumocoque”. Revue de Medecine Interne5 (2008): 412-414.

Berrin Ergun-Longmire., et al. "Seizure-Like Activity in an Adolescent with Fahr Syndrome". EC Paediatrics 13.8 (2024): 01-05.