EC Paediatrics

Research Article Volume 12 Issue 2 - 2023

Retrospective Review of Patients with Kawasaki Disease from a Single Center in United Arab Emirates

Nazima Chaudhary1*, Mohammed Wajid Chaudhary1, Naavarasu Sundaramurthy1, Anas Abu Hazeem2 and Dinesh Banur Onkarappa1

1Department of Pediatrics, NMC Royal Hospital, Abu Dhabi, United Arab Emirates
2Pediatric Cardiology, KidsHeart Medical Center, Abu Dhabi, United Arab Emirates

*Corresponding Author: Nazima Chaudhary, Department of Pediatrics, NMC Royal Hospital, Abu Dhabi, United Arab Emirates.
Received: January 19, 2023; Published: January 28, 2023

What is already known on this topic?

  • Significant proportion of children with KD have coronary artery abnormalities.
  • Multiple risk factors for CAAs include increased inflammatory markers like CRP and ESR, hepatic dysfunction and delayed treatment with IVIG.

What this study adds?

  • Hepatic enzymes levels are significantly higher in those with CAAs, though absolute levels may still be within normal limits for age and sex.

Keywords: Kawasaki Disease (KD); C-Reactive Protein (CRP); Echocardiography (ECHO); Coronary Artery (CA)

  1. Kawasaki T. “Acute febrile muco-cutaneous lymph node syndrome in young children with unique digital desquamation”. Japanese Journal of Allergology 16 (1967): 178-222.
  2. Uehara R and Belay ED. “Epidemiology of Kawasaki disease in Asia, Europe, and the United States”. Journal of Epidemiology2 (2012): 79‐85.
  3. McCrindle BW., et al. “Diagnosis, treatment, and long-term management of Kawasaki disease: a scientific statement for health professionals from the American Heart Association”. Circulation 135 (2017): e927-e999.
  4. Kobayashi T., et al. “A New Z Score Curve of the Coronary Arterial Internal Diameter Using the Lambda-Mu-Sigma Method in a Pediatric Population”. The Journal of the American Society of Echocardiography8 (2016): 794-801.
  5. Makino N., et al. “Descriptive epidemiology of Kawasaki disease in Japan, 2011-2012: from the results of the 22nd nationwide survey”. Journal of Epidemiology3 (2015): 239-245.
  6. Holman RC., et al. “Hospitalizations for Kawasaki syndrome among children in the United States, 1997–2007”. The Pediatric Infectious Disease Journal 29 (2010): 483-488.
  7. Nakamura Y., et al. “Incidence rate of recurrent Kawasaki disease in Japan”. Acta Paediatrica 83 (1994): 1061-1064.
  8. Mori M., et al. “Meta-analysis of the results of intravenous gamma globulin treatment of coronary artery lesions in Kawasaki disease”. Modern Rheumatology 14 (2004): 361-366.
  9. Dominguez SR., et al. “Preventing coronary artery abnormalities: a need for earlier diagnosis and treatment of Kawasaki disease”. The Pediatric Infectious Disease Journal12 (2012): 1217-1220.
  10. Gorczyca D., et al. “The clinical profile of Kawasaki disease of children from three Polish centers: a retrospective study”. Rheumatology International6 (2014): 875-880.
  11. Al-Ammouri I., et al. “Kawasaki disease in Jordan: demographics, presentation, and outcome”. Cardiology in the Young4 (2012): 390-395.
  12. Ghelani SJ., et al. “Increased incidence of incomplete Kawasaki disease at a pediatric hospital after publication of the 2004 American heart association guidelines”. Annals of Pediatric Cardiology 33 (2012): 1097-1103.
  13. Heuclin T., et al. “Increased detection rate of Kawasaki disease using new diagnostic algorithm, including early use of echocardiography”. The Journal of Pediatrics5 (2009): 695-699.
  14. De Ferranti SD., et al. “Association of Initially Normal Coronary Arteries with Normal Findings on Follow-up Echocardiography in Patients with Kawasaki Disease”. JAMA Pediatrics12 (2018): e183310.
  15. Chbeir D., et al. “Kawasaki disease: abnormal initial echocardiogram is associated with resistance to IV Ig and development of coronary artery lesions”. Pediatric Rheumatology1 (2018): 48.
  16. Tsujii N., et al. “Late Wall Thickening and Calcification in Patients After Kawasaki Disease”. The Journal of Pediatrics 181 (2017): 167-171.
  17. Kahn AM., et al. “Calcium scoring in patients with a history of Kawasaki disease”. JACC Cardiovasc Imaging 5 (2012): 264-272.
  18. Kato H., et al. “Long-term consequences of Kawasaki disease. A 10- to 21-year follow-up study of 594 patients”. Circulation6 (1996): 1379-1385.
  19. Burns JC., et al. “Sequelae of Kawasaki disease in adolescents and young adults”. Journal of the American College of Cardiology 28 (1996): 253-257.
  20. Mammadov G., et al. “Hepatic dysfunction secondary to Kawasaki disease: characteristics, etiology and predictive role in coronary artery abnormalities”. Clinical and Experimental Medicine1 (2020): 21-30.
  21. Uehara R., et al. “Serum alanine aminotransferase concentrations in patients with Kawasaki disease”. The Pediatric Infectious Disease Journal9 (2003): 839-842.
  22. Nomura Y., et al. “Patients diagnosed with Kawasaki disease before the fifth day of illness have a higher risk of coronary artery aneurysm”. Pediatrics International4 (2002): 353-357.
  23. Tang Y., et al. “Epidemiological and Clinical Characteristics of Kawasaki Disease and Factors Associated with Coronary Artery Abnormalities in East China: Nine Years Experience”. Journal of Tropical Pediatrics2 (2016): 86-93.
  24. Yan F., et al. “Risk Factors of Coronary Artery Abnormality in Children with Kawasaki Disease: A Systematic Review and Meta-Analysis”. Frontiers in Pediatrics 7 (2019): 374.
  25. Printz BF., et al. “Pediatric heart network investigators. Noncoronary cardiac abnormalities are associated with coronary artery dilation and with laboratory inflammatory markers in acute Kawasaki disease”. Journal of the American College of Cardiology 57 (2011): 86-92.

Nazima Chaudhary., et al. Retrospective Review of Patients with Kawasaki Disease from a Single Center in United Arab Emirates. EC Paediatrics 12.2 (2023):61-69.