EC Paediatrics

Research Article Volume 12 Issue 3 - 2023

Prevalence of Vitamin D Deficiency in Children with Inherited Ichthyosis: A Transversal Controlled Study

K Oujennane1,2*, S Essoli3,4, L Darfaoui5, M Aboudourib1,2, S Amal1,2, S Aboulmakarim5, L Adarmouch3,4 and O Hocar1,2

1Dermatology Department, Mohammed VI University Hospital, Marrakesh, Morocco
2Bioscience and Health Research Laboratory, Faculty of Medicine, Cadi Ayyad University (UCA), Marrakesh, Morocco
3Clinical Research Department, Mohammed VI University Hospital, Marrakesh, Morocco
4Community Medicine and Public Health Department, Bioscience and Health Research Laboratory, Faculty of Medicine and pharmacy, Cadi Ayyad University (UCA), Marrakesh, Morocco
5Department of biochemistry, Mohammed VI University Hospital, Marrakesh, Morocco

*Corresponding Author: K Oujennane, Dermatology Department, Mohammed VI University Hospital, Marrakesh, Morocco.
Received: February 17, 2023; Published: February 27, 2023



Introduction and Objective: Inherited ichthyosis constitutes a heterogeneous group of cornification disorders. Its healthcare management is a challenge for most specialists doctors in dermatology. The objective of this study was to determine the prevalence of vitamin D deficiency of patients suffering from inherited ichthyosis, and to identify the different factors associated with this deficiency.

Methodology: This was a cross sectional study performed in the University Hospital center at the dermatology department among two groups: patients with inherited ichthyosis and patients without this disease. Patients’ clinical characteristics were collected. Serum concentration of 25-hydroxyvitamin D was determined among the two groups. Comparisons between the two groups conducted by bivariate analysis.

Results: A total of 46 patients were included in the study. The majority (84.8%) had serum 25-hydroxyvitamin D below the optimal level of 30 ng/mL. Among patients with inherited ichthyosis, 56.5% had a lamellar form, 39.1% had a vulgaris form and 01 case had netherton disease. The mean of serum level of 25-hydroxyvitamin D was lower at in patients with inherited ichthyosis 18.24 ± 10 ng/mL in comparison with control group 22.0 ± 15.0, (p = 0.19). The vulgaris ichthyosis form was mainly associated to ectropion (p = 0,02) and thick dander scales (p = 0.001).

Conclusion: The measure of vitamin D among patients with inherited ichthyosis was suboptimal. A supplementation in vitamin D is strongly recommended to this category of patients either severe ichthyosis or lamellar ichthyosis.

Keywords: Inherited Ichthyosis; Vitamin D

K Oujennane., et al. Prevalence of Vitamin D Deficiency in Children with Inherited Ichthyosis: A Transversal Controlled Study. EC Paediatrics 12.3 (2023):60-65.