EC Paediatrics

Review Article Volume 14 Issue 4 - 2025

Overview for Congenital Deformities of Hand in Children

Nguyen Ngoc Hung*

Surgical Department, Vietnam National Hospital for Pediatric, Ha Noi Medical University, Vietnam

*Corresponding Author: Nguyen Ngoc Hung, Surgical Department, Vietnam National Hospital for Pediatric, Ha Noi Medical University, Vietnam.
Received: March 07, 2025; Published: March 26, 2025



Congenital hand differences encompass a range of structural abnormalities that impact the function, appearance, and psychosocial domains of affected children. Continued advances in the understanding and treatment of these differences continue to shape management. Over the years, new developments have been made in the areas of molecular genetics, non-invasive treatments, surgical techniques, and outcome measures in some of the most common congenital hand differences. Applying these advances in the understanding and management of congenital hand differences will help surgeons achieve the best possible outcomes for these children
Keywords: Congenital Hand Deformities; Trigger Thumb; Bifid Thumb; Radial Club Hand; Syndactyly

  1. Oberg KC. “Classification of congenital upper limb anomalies: towards improved communication, diagnosis, and discovery”. Journal of Hand Surgery (European Volume) 44.1 (2019): 4-14.
  2. Sullivan MA and Adkinson JM. “Congenital hand differences”. Plastic Surgical Nursing 36.2 (2016): 84-89.
  3. Ekblom AG., et al. “Epidemiology of congenital upper limb anomalies in 562 children born in 1997 to 2007: a total population study from Stockholm, Sweden”. Journal of Hand Surgery (American Volume) 35.11 (2010): 1742-1754.
  4. Koskimies E., et al. “Congenital upper limb deficiencies and associated malformations in Finland: a population-based study”. Journal of Hand Surgery (American Volume) 36.6 (2011): 1058-1065.
  5. Castilla E., et al. “Polydactyly: a genetic study in South America”. American Journal of Human Genetics 25.4 (1973): 405-412.
  6. Wassel HD. “The results of surgery for polydactyly of the thumb”. Clinical Orthopaedics and Related Research 64 (1969): 175-193.
  7. Zuidam JM., et al. “A classification system of radial polydactyly: inclusion of triphalangeal thumb and triplication”. Journal of Hand Surgery (American Volume) 33A.3 (2008): 373-737.
  8. Horii E., et al. “Duplicated thumb bifurcation at the metacarpophalangeal joint level: factors affecting surgical outcome”. Journal of Hand Surgery (American Volume) 22A.4 (1997): 671-679.
  9. Harris MF. “Milestones in pediatric anesthesia risk”. In: Carter PR, ed. Reconstruction of the Child’s Hand. Philadelphia: Lea & Febiger (1991): 3.
  10. Flatt AE. “Growth, Size and Function”. In: Flatt AE, ed. The Care of Congenital Hand Anomalies. St. Louis, MO: Quality Medical Publishing, Inc., i (1994): 25.
  11. Hung NN. “Bifid thumb type IV in children: transferring an epiphyseal segment of the proximal phalanx with insertion of the abductor pollicis brevis tendon”. Journal of Children’s Orthopaedics 4.6 (2010): 525-537.
  12. Montgomery WF. “Observation on the spontaneous amputation of the limbs of the fetus in utero, with an attempt to explain the occasional cause of its production”. Dublin Journal of Medical and Chemical Science 1 (1832): 140-144.
  13. Gorlin RJ., et al. “Syndromes of the head and neck, 4th edition”. Oxford University Press, New York: 10-13.
  14. Upton J. “Constriction ring syndrome”. In: Mathes SJ, Hentz UR (eds) Plastic surgery. Elsevier, Philadelphia (2006): 185-213.
  15. Streeter GL. “Focal deficiencies in fetal tissues and their relation to intrauterine amputation”. Contributions to Embryology 22.126 (1930).
  16. Bamforth JS. “Amniotic band sequence: Streeter’s hypothesis reexamined”. American Journal of Human Genetics 44.3 (1992): 280-287.
  17. Gogola G. “The pediatric upper extremity”. 1st edition (Abzug J, Kozin S, Zlotolow D, eds.). New York, NY: Springer (2015).
  18. Percival NJ and Sykes PJ. “Syndactyly: a review of the factors which influence surgical treatment”. Journal of Hand Surgery (British Volume) 14B.2 (1989): 196-200.
  19. Wilkie AOM., et al. “Apert syndrome results from localized mutations of FGFR2 and is allelic with Crouzon syndrome”. Nature Genetics 9.2 (1995): 165-172.
  20. Jenkins D., et al. “RAB23 mutations in Carpenter syndrome imply an unexpected role for hedgehog signaling in cranial-suture development and obesity”. American Journal of Human Genetics 80.6 (2007): 1162-1170.
  21. Howard TD., et al. “Mutations in TWIST, a basic helix-loop-helix transcription factor in Saethre-Chotzen syndrome”. Nature Genetics 15.1 (1997): 36-41.
  22. Cohen DM., et al. “Acrocephalopolysyndactyly type II--Carpenter syndrome: clinical spectrum and an attempt at unification with Goodman and Summitt syndromes”. American Journal of Human Genetics 28.2 (1987): 311-324.
  23. Muenke M., et al. “A common mutation in the fibroblast growth factor receptor 1 gene in Pfeiffer syndrome”. Nature Genetics 8.3 (1994): 269-274.
  24. Dobyns JH. “Syndactyly”. In Green DP, Hotchkiss RN (eds): Operative Hand Surgery, ed 3. New York, NY: Churchill Livingstone, volume 1 (1993): 346-363.
  25. Johnston O and Kirby VV. “Syndactyly of the ring and little finger”. American Journal of Human Genetics 7.1 (1955): 80-82.
  26. Temtamy SA and McKusick VA. “The genetics of hand malformations”. Birth Defects: Original Article Series 14.3 (1978): 1-619.
  27. Kelikian H. “Syndactyly, in Congenital Deformities of the Hand and Forearm”. Philadelphia, PA: WB Saunders (1974): 331-407.
  28. Orel H. “Kleine Beitrage zur Vererbungswissenschaft. Synostosis metacarpi quarti et quinti”. Z-Anatomy 14 (1928): 244-252.
  29. Upton J. “Congenital anomalies of the hand and forearm”. I: McCarthy JG, red. Plastic surgery. New York, NY: WB Saunders, 8 (1990): 5218-5398.
  30. Tickle C. “Embryology”. I: Gupta A, Kay SPJ, Scheker LR, red. The growing hand. London: Mosby, 5 (2000): 25-32.
  31. Flatt AE. “Webbed fingers”. I: Flatt AE, red. The care of congenital hand anomalies. St. Louis, MO: Quality Medical Publishing (1994): 228-275.
  32. Waters PM and Bae DS. “Embryology and development”. I: Waters PM, Bae DS, red. Pediatric hand and upper limb surgery. A practical guide. Philadelphia, PA: Lippincott Williams & Wilkins 1 (2012): 1-11.
  33. Ikegawa M., et al. “Syndactyly and preaxial synpolydactyly in the single Sfrp2 deleted mutant mice”. Developmental Dynamics 237.9 (2008): 2506-2517.
  34. Dao KD., et al. “Surgical treatment of congenital syndactyly of the hand”. Journal of the American Academy of Orthopaedic Surgeons 12.1 (2004): 39-48.
  35. Tonkin MA. “Failure of differentiation part I: Syndactyly”. Hand Clinics 25.2 (2009): 171-193.
  36. Goodman FR., et al. “Synpolydactyly phenotypes correlate with size of expansions in HOXD13 polyalanine tract”. Proceedings of the National Academy of Sciences of the United States of America 94.14 (1997): 7458-7463.
  37. Buck-Gramcko D. “Radialization as a new treatment for radial club hand”. Journal of Hand Surgery (American Volume) 10A.6.2 (1985): 964-968.
  38. D’Arcangelo M., et al. “Radial club hand”. In: Gupta A, Kay SPJ, Scheker LR, eds. The Growing Hand: Diagnosis and Management of the Upper Extremity in Children. London: Harcourt Publishers Ltd (2000): 147-170.
  39. Bayne LG and Klug MS. “Long term review of the surgical treatment of radial deficiencies”. Journal of Hand Surgery (American Volume) 12.2 (1987): 169-179.
  40. Heikel HV. “Aplasia and hypoplasia of the radius: studies on 64 cases and on epiphyseal transplantation in rabbits with the imitated defect”. Acta orthopaedica Scandinavica, Supplementum 39 (1959): 1-155.
  41. Manske PR., et al. “Centralization of the radial club hand: an ulnar surgical approach”. Journal of Hand Surgery 6.5 (1981): 423-433.
  42. Sayre RH. “A contribution to the study of club-hand”. Transactions of the American Orthopedic Association 6 (1893): 208-216.
  43. Lister G. “Reconstruction of the hypoplastic thumb”. Clinical Orthopaedics and Related Research 66 (1969): 109-112.
  44. Takagi T., et al. “Bone lengthening of the radius with temporary external fixation of the wrist for mild radial club hand”. Journal of Plastic, Reconstructive and Aesthetic Surgery 67.12 (2014): 1688-1693.
  45. Carroll RE. “Pollicization”. In Operative Hand Surgery(ed.) Green DP, 2nd edition (New York: Churchill Livingstone) (1988): 2263-2280.
  46. Albee FH. “Formation of radius congenitally absent. Conditions seven years after implantation of bone graft”. Annals of Surgery 87.1 (1928): 105-110.
  47. Starr DE. “Congenital absence of the radius. A method of surgical correction”. The Journal of Bone and Joint Surgery. American Volume 27A.4 (1945): 572-577.

Nguyen Ngoc Hung. “Overview for Congenital Deformities of Hand in Children”. EC Paediatrics 14.4 (2025): 01-44.