EC Paediatrics

Bipolar disorder (BD) is a mood disorder characterized by abnormal neurotransmitter systems. Serotonin and serotonin transporter gene (5-HTTLPR) are associated with this dysfunction. Medications, such as carbamazepine and lamotrigine, can affect dopaminergic signaling and glutamate transmission, both of which are relevant in managing manic and depressive episodes in bipolar disorder. The GABAergic system may also play a critical role in the pathophysiology of bipolar disorder and polymorphisms related to various neurotransmitter receptors, including those for serotonin (5-HT2C) and dopamine (DRD2), have been associated with alterations in mood disorders.

Keywords: Bipolar Disorder (BD); 5-HTTLPR; Serotonin; Dopamine

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