EC Paediatrics

Case Series Volume 12 Issue 9 - 2023

Neonatal Dengue, Case Series

César Eduardo Juárez Campos1*, Daniel Duran Guerra2, Oscar Eduardo Ceja Mejía1, Daniel Cortez Comparan1, Javier Abel Baeza Casillas1, David Enrique Diaz Santana Bustamante2, Yuriria Berenice Benavides Garcia3, Katy Lizeth Reyes Hernández3, Ulises Reyes Gómez4, Guillermo Uribe Ramos2,4, Napoleón González Saldaña1, Sofía Jacqueline Baeza Magaña2, Maria Elena Vargas Mosso5 and Carlos Uriel Mercado Díaz2

1Neonatology Service of the General Hospital of the West, Jalisco Health Secretariat, Mexico
2Grupo de Investigación en Infectología Pediátrica (GIIP), A.C., Mexico
3Epidemiology Service of the General Hospital of the West, Ministry of Health Jalisco, Mexico
4Pediatric Research Unit, San Rafael Pedagogical Institute, San Luis Potosí, Mexico
5Student of the Faculty of Medicine of the University of Guadalajara, Mexico

*Corresponding Author:César Eduardo Juárez Campos, Neonatology Service of the General Hospital of the West, Jalisco Health Secretariat, Mexico.
Received: August 11, 2023; Published: August 24, 2023



Dengue is a viral infectious disease, it represents a problem for public health worldwide due to its morbidity and mortality. Four serotypes have been reported: DENV-1, DENV-2, DENV-3, DENV-4. Mexico is an endemic country. A series of five cases of neonatal dengue is reported from the neonatal area of the General Hospital of the West, of the Health Services of Jalisco, México, detected from February to November 2019. The importance of this report is its presentation at this age where this pathology is rare, transmission was vertical and occurred in the first days of life. The newborns had variable symptoms of the disease, one was classified as severe dengue with shock and hemorrhage. The clinical report of suspicion was confirmed with the serological diagnosis NS1/IgM (+), predominating serotype DENV-2. Vertical transmission should be suspected in high-risk areas, to maintain surveillance and once diagnosed, provide timely treatment, as well as promote the implementation of specific diagnostic and therapeutic guidelines for the neonatal stage.

Keywords: Dengue; Timely Diagnosis; Morbidity and Mortality; Neonatal Period; NS1/IgM Serology; DENV-2 Serotype

  1. Murray NE., et al. “Epidemiology of dengue: past, present and future prospects”. Clinical Epidemiology 5 (2013): 299-309.
  2. Laserna A., et al. “Economic impact of Dengue fever in Latin America and the Caribbean: a systematic review”. Pan American Journal of Public Health 42 (2018): e111.
  3. Wilder SA., et al. “Dengue”. Lancet10169 (2019): 350-363.
  4. Beltrán-Silva SL., et al. “Clinical and differential diagnosis: dengue, Chikungunya and Zika”. Revista Médica Del Hospital General de México3 (2018): 146-153.
  5. Harapan H., et al. “Dengue: A minireview”. Viruses 8 (2020): 1-35.
  6. Torres-Galicia I., et al. “Dengue en México: análisis de dos décadas”. Gaceta Médica de México 150 (2014): 122-127.
  7. Gupta SG and Kumar S. “An overview of factors affecting dengue transmission in Asian region and its predictive models”. Journal of Applied and Natural Science3 (2020): 460-470.
  8. Organización Panamericana de la Salud/Organización Mundial de la Salud. Guías de atención para enfermos de Dengue en la región de las Américas (2010).
  9. Organización Mundial de la Salud (OMS). Dengue y Dengue grave (2019).
  10. Jain J., et al. “Perinatal transmission of dengue infection in a preterm neonate: a case report”. Tropical Doctor3 (2019): 239-240.
  11. Halstead SB and Dans LF. “Dengue infection and advances in dengue vaccines for children”. The Lancet Child and Adolescent Health10 (2019): 734-741.
  12. Ribeiro CF., et al. “Perinatal transmission of dengue: A report of 7 cases”. The Journal of Pediatrics5 (2013): 1514-1516.
  13. Arteaga-Livias K., et al. “Dengue en un neonato”. Revista Chilena de Infectología5 (2017): 494-498.
  14. Bopeththa BVKM., et al. “A case report of dengue haemorrhagic fever during the peripartum period: Challenges in management and a case of vertical dengue transmission”. BMC Infectious Diseases1 (2018): 4-7.
  15. Pérez Molina JJ., et al. “Enfermedad de membrana hialina: Mortalidad y factores de riesgo maternos y neonatales”. Revista de Ginecología y Obstetricia de México7 (2006): 354-359.
  16. Feitoza HAC., et al. “Dengue infection during pregnancy and adverse maternal, fetal, and infant health outcomes in Rio Branco, Acre State, Brazil, 2007-2012”. Cadernos de Saude Publica5 (2017): e00178915.
  17. Brar R., et al. “Maternal and fetal outcomes of dengue fever in pregnancy: a large prospective and descriptive observational study”. Archives of Gynecology and Obstetrics (2021).
  18. MacHain-Williams C., et al. “Maternal, Fetal, and Neonatal Outcomes in Pregnant Dengue Patients in Mexico”. BioMed Research International (2018).
  19. Mubashir M., et al. “Dengue and malaria infections in pregnancy: Maternal, fetal and neonatal outcomes at a tertiary care hospital”. Wiener klinische Wochenschrift7-8 (2020): 188-196.
  20. Report C. CAse report vertical transmission of dengue infection: the first putative 1 (2016): 14-17.
  21. Guía de práctica clínica. SSA – 151-08-GRR.Manejo del dengue no grave y el dengue grave, México: Secretaría de Salud (2015).
  22. Kesetyaningsih TW., et al. “Determination of environmental factors affecting Dengue incidence in sleman district, yogyakarta, indonesia”. African Journal of Infectious Diseases1 (2018): 13-25.
  23. Arredondo GJ., et al. “Panorama epidemiológico de dengue en México 2000-2019”. Revista Latinoamericana de Infectología Pediátrica2 (2020): 78-83.
  24. Fernandes-Ribeiro C., et al. “Perinatal Transmission of Dengue: a Report of 7 Cases”. The Journal of Pediatrics5 (2013): 1514-1516.
  25. Xueru YIN., et al. “Vertical transmission of dengue infection: the first putative case reposted in China”. Revista do Instituto de Medicina Tropical de São Paulo 58 (2016): 90.
  26. Xiong YQ., et al. “Dengue virus infection during pregnancy increased the risk of adverse fetal outcomes? An updated meta-analysis”. Journal of Clinical Virology 94 (2017): 42-49.
  27. Alallah J., et al. “Congenital dengue in a Saudi neonate: A case report”. Journal of Neonatal-Perinatal Medicine2 (2020): 279-282.
  28. Haryanto S., et al. “Clinical features and virological confirmation of perinatal dengue infection in Jambi, Indonesia: A case report”. The International Journal of Infectious Diseases 86 (2019): 197-200.
  29. Romero SE., et al. “Dengue Neonatal Presentación de Casos Clínicos”. Revista de Ginecología y Obstetricia de México 83 (2015): 308-315.
  30. Arredondo-García JL., et al. “Arbovirus en Latinoamérica”. Acta Pediátrica de México2 (2016): 111-131.

César Eduardo Juárez Campos., et al. Neonatal Dengue, Case Series. EC Paediatrics 12.9 (2023): 01-06.