EC Paediatrics

Enterovirus is a RNA virus that belongs to the Picornaviridae family and can be classified into 4 different species. neonatal enterovirus infection is common but is usually asymptomatic. There are case reports from literature of enterovirus infection which describe a large variety of symptoms which seems to affect more severely neonates than older children. The present case report described a two day old newborn who started with weight loss greater than 10% regarding birth weight, jaundice and lethargy. Progressive neurological worsening which includes seizures and persistent apnea episodes requiring mechanical respiratory support. Additional tests suggesting neonatal sepsis. Neurological approach with positive RNA for Enterovirus in cerebrospinal fluid. 

Keywords: Enterovirus; Early Onset Sepsis; Neonatal Enterovirus; Neonatal Sepsis

1. Zhang M., et al. “Clinical characteristics of severe neonatal enterovirus infection: A systematic review”. BMC Pediatrics (2021): 21.
2. Chuang Y-Y and Huang Y-C. “Enteroviral infection in neonates”. Journal of Microbiology, Immunology and Infection (2019).
3. Chen W., et al. “Clinical characterization of benign enterovirus infection in neonates”. Medicine (2021): 100.
4. Wörner N., et al. “Enterovirus-A71 rhombencephalitis outbreak in Catalonia: Characteristics, management and outcome”. Pediatric Infectious Disease Journal 40 (2021): 628-633.
5. Abzug Markj., et al. “Profile of enterovirus disease in the first two weeks of life”. The Pediatric Infectious Disease Journal 12 (1993): 820-823.
6. Noor A and Krilov LR. “Enterovirus infections”. Pediatrics in Review 12 (2016): 505-515.
7. Chen W., et al. “Clinical characterization of benign enterovirus infection in neonates”. Medicine (2021): 100.
8. CDC non-polio Enterovirus (2022).