EC Paediatrics

Research Article Volume 12 Issue 5 - 2023

Clinical Patterns of Typhoid Fever in Children in Zimbabwe

IC Chikanza1,2*, TA Mazodze3, K Nathoo4 and CML Olweny5

1International Arthritis and Hypermobility Centre @ Harley Street Clinic, London WIG 7AF, UK
2Department of Medicine, Catholic University, Harare, Zimbabwe
3Department of Pediatrics and Child Health, University of Zimbabwe, Harare, Zimbabwe
4Department of Pediatrics and Child Health, Harare Teaching Hospital, Harare, Zimbabwe
5Uganda Cancer Institute, Upper Mulago Hill Road Kampala, Uganda

*Corresponding Author: IC Chikanza, International Arthritis and Hypermobility Centre @ Harley Street Clinic, London WIG 7AF, UK and Department of Medicine, Catholic University, Harare, Zimbabwe. E-mail:
Received: February 20, 2023; Published: April 25, 2023

The clinical, serological, hematological and biochemical features of bacteriologically proven typhoid fever were assessed prospectively in 218 children in Zimbabwe over a 3 year period. The most predictive clinical features most useful in diagnosing pediatric typhoid fever, were fever with relative bradycardia, abdominal pain and diarrhea. Though there was a high incidence of complications, treatment with chloramphenicol was associated with a good outcome. Hepatic involvement occurred in 28% (61), 3.7% (8) had myocarditis, 14.7% (32) had renal complications, 8% (6) developed gastrointestinal complications whilst neuropsychiatric manifestations occurred in 55.5% (121) of cases. For the Widal test, H titres were a more sensitive indicator of infection, being found in 57,3% of culture positive cases compared with 33.5% for O. The relapse rate was 1.8% whilst the mortality rate was 0.45%.

Keywords: Typhoid Fever (TF); Widal Test (WT); Children

  1. Bulletin of the World Health of Health 64.2 (1986): 271.
  2. Hook EW. “Typhoid fever today”. The New England Journal of Medicine 1 (1984): 116-118.
  3. Huckstep RL. “Typhoid fever and other Salmonella infections”. E and S Livingstone Ltd, Edinburgh (1962).
  4. Gulati PD., et al. “Changing pattern of typhoid fever”. The American Journal of Medicine 45 (1968): 554.
  5. Gupta SP., et al. “Current clinical patterns of typhoid fever: a prospective study”. American Journal of Tropical Medicine and Hygiene 88 (1985): 377-378.
  6. Khalap NV. “Typhoid fever in children”. Indian Journal of Child Health 6 (1957): 799.
  7. Samantray SK., et al. “Enteric fever. An analysis of 500 cases”. Practitioner 218 (1977): 400-408.
  8. Manson-Bahr PEC and Apted FIC. “Manson's Tropical Diseases”. 18th Edition, Bailliere Tindall, London (1982).
  9. Stuart BH and Pullen RL. “Typhoid. An analysis of 360 cases”. Archives of Internal Medicine 78 (1946): 629.
  10. Prabhu MG. “Some observations in typhoid fever”. Journal of Indian Medical Association 25 (1955): 122.
  11. Chikanza IC., et al. “Clinical patterns of typhoid fever in adults in Zimbabwe: A prospective study”. (in press) (1985).
  12. Watson KC. “Response to chloramphenicol in the treatment of typhoid fever”. South African Medical Journal 27 (1953): 1054-1057.
  13. Goldman JM. Principle of clinical electrocardiograph.
  14. 14 Lange Medical Publication California (1962): 267.
  15. GBD 2017 Typhoid and Paratyphoid Collaborators”. The Lancet Infectious Diseases 19 (2019): 369-381.

IC Chikanza., et al. Clinical Patterns of Typhoid Fever in Children in Zimbabwe. EC Paediatrics 12.5 (2023):23-27.