EC Paediatrics

Research Article Volume 14 Issue 6 - 2025

Climacteric Syndrome (40 - 65 Years) and Healthy Aging - Primary Preventive Care for Healthy Female Aging

Fabio Henrique Seixas1, Ricardo B Feitosa2, Renata Iannetta3, Rodrigo Alves Ferreira4 and Odilon Iannetta5*

1Physical Education Professional, Specialist in Resistance Training (USP-SP), Technologist at DBM Box, Ribeirão Preto-SP, Brazil
2Gynecologist Doctor Maternal Leonor Mendes de Barros-SP Capital, Brazil
3PhD in Gynecologist Faculdade de Medicina USP, Ribeirão Preto, SP-Brazil and Managing Director of Climaterium® Ltd, Brazil
4PhD Gynecologist at the Faculty of Ribeirão Preto-USP and Associate Professor at the Federal University of São Carlos, SP, Brazil
5PhD Gynecologist Retired, Senso Stricto, Clinical Director of Climatérium® Ltd, Ribeirão Preto, Brazil

*Corresponding Author: Odilon Iannetta, PhD Gynecologist Retired, Senso Stricto, Clinical Director of Climatérium® Ltd, Ribeirão Preto, Brazil.
Received: April 09, 2025; Published: May 21, 2025



On average, women experience menopause around the age of 50. Therefore, with the increase in life expectancy, women may spend approximately 40% of their lives in the postmenopausal period [2]. The present study aims at analyzing the potential contribution Primary Preventive Care (PPC) to healthy aging by screening the four most affected systems during the Climacteric. From May 1, 1999, to December 31, 2016, 2,093 patients were treated at the Climacteric outpatient clinic of the University FMRP-USP). The medical records of the patients were retrospectively analyzed, excluding those with one or more of the conditions that cause early failure, of 305 patients in the climacteric without underlying organic diseases included in this study. Among these patients, one hundred and twenty-seven (41.6%) reported musculoskeletal symptoms and performed lumbar DEXA with a normal result (T score > -1.0). By applying the concepts of New Bone Biology (Protein and Inorganic Matrix), we were able to evaluate the state of the two bone matrices; Iannetta and colleagues [8]. This detailed study opens a broad field of practical applications by enabling the early prevention of chronic noncommunicable diseases during the climacteric. Exacerbated by modern occupations, these age-related diseases hinder healthy aging in women. The world population is undergoing a rapid aging process [1]. Understanding the final stage of life and providing appropriate preventive measures are crucial for promoting healthy aging. For these purposes, physicians should monitor plasma hormone levels and conduct ancillary tests in different organs, in addition to performing genetic testing appropriate for each case, under specific circumstances, before discussing the types, risks, start and duration of HRT. In this study, ruling out organic diseases associated with the four most affected (skeletal, cardiovascular, endocrine and psychiatric) systems during the climacteric, enabled us to determine that the hypothalamic centers (thermoregulatory and sleep-wake centers) give rise to clinical symptoms from the onset of hormonal deregulation. These clinical symptoms specifically originate from the four systems without organic disease This study places gynecologists at the forefront of knowledge, minimizing the sensation of premature aging, which contradicts the conditions of healthy aging, thereby confirming the aphorism that: “We were not born to die from chronic noncommunicable diseases” [12]. Gynecologists play a key role by facilitating the long-desired healthy aging. To this end, they must promptly diagnose patients with the Pure Climacteric Syndrome.

 Keywords: Life Expectancy at Birth (LEB); Coronavirus Disease 2019 (COVID-19); Primary Preventive Care (PPC)

  1. Department of Economic and Social Affairs PDW. World Population Prospects 2024: Summary of Results 2024.
  2. Takahashi TA and Johnson KM. “Menopause”. Medical Clinics of North America3 (2015): 521-534.
  3. Verdonk P., et al. “Menopause and work: A narrative literature review about menopause, work and health”. Work 2 (2022): 483-496.
  4. Griffiths A. “Improving recognition in the UK for menopause-related challenges to women's working life”. Post Reproductive Health 4 (2017): 165-169.
  5. Calixto N., et al. “A nova biologia óssea: rastreamento precoce de formação e deterioração do tecido ósseo - artigo de revisão e atualização [The new bone biology: early screening of bone tissue deterioration review and update article]”. RBUS - Revista Brasileira de Ultrassonografia 9 (2010): 10-17.
  6. Iannetta O and Ferreira R. “Osteo-sonografia e osteo-sonometria da metáfise óssea em falange de 32 adolescentes. Metodologia para avaliação da qualidade óssea. Estudo piloto. [Osteosonography and osteosonometry of bone methaphysys as an evaluation test of bone quality: pilot study]”. Reprodução & Climatério 1 (2003): 6.
  7. Iannetta R., et al. “New bone biology. New scenario: Practical tracking of the two matrices (Proteica and inorganic) in 192 subjects in adolescence”. EC Paediatrics8 (2020): 191-197.
  8. Iannetta R., et al. “Análise da Topologia Óssea em 2.140 pacientes no Período do Climatério. Predição do Risco de Fraturas Osteoporóticas na Senilidade [Analysis of bone topology in 2,140 patients during the climateric period. Prediction of the risk of osteoporotic fractures of old age]”. Reprodução & Climatério 23 (2008): 26-31.
  9. Wuster C., et al. “Usefulness of quantitative ultrasound in evaluating structural and mechanical properties of bone: comparison of ultrasound, dual-energy X-ray absorptiometry, micro-computed tomography, and mechanical testing of human phalanges in vitro”. Technology and Health Care 6 (2005): 497-510.
  10. Obstetrícia F-FBdAdGe. Manual de Orientação Climatério [Climate Guidance Manual]. Brazil: FEBRASGO [Brazilian Federation of Gynecology and Obstetrics Societies (Federação Brasileira das Sociedades de Ginecologia e Obstétrícia)] (2010).
  11. Goncalves EM., et al. “Brazilian pediatric reference data for quantitative ultrasound of phalanges according to gender, age, height and weight”. PLoS One6 (2015): e0127294.
  12. Iannetta O. “Atualizar os conhecimentos é preciso: estado atual da avaliação óssea no climatério [Knowledge must be updated: the current state of bone assessment in the climacteric]”. Femina 7 (2006b): 451-453.

Odilon Iannetta., et al. "Climacteric Syndrome (40 - 65 Years) and Healthy Aging - Primary Preventive Care for Healthy Female Aging". EC Paediatrics 14.6 (2025): 01-05.