Review Article Volume 14 Issue 10 - 2025

Brain-Gut Interaction Disorders in Infants and Preschoolers: How are we Finalizing the Practice of the Rome IV Criteria, and what are the Expectations for the Next Step

Nilton Carlos Machado*, Juliana Tedesco Dias, Gabriela Nascimento Hercos, Carine Dias Ferreira de Jesus and Mary de Assis Carvalho

Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Botucatu Medical School, São Paulo State University, Botucatu, São Paulo, Brazil

*Corresponding Author: Nilton Carlos Machado, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Botucatu Medical School, São Paulo State University, Botucatu, São Paulo, Brazil.
Received: September 15, 2025; Published: September 29, 2025



Background: This commentary will delve into our well-lived real-world experience with the seven disorders of brain-gut interaction in infants and preschoolers, and prepare for the transition to the Rome V Criteria. Brain-gut interaction disorders in children is a disease that has been focused on by both General Paediatricians as well as Pediatric Gastroenterologists.

Objective of the Study: The objective of this commentary is to present the Rome IV Criteria and share valuable experiences gathered over the past ten years. Additionally, it offers insights into what the forthcoming Rome V criteria will enhance our understanding of brain-gut interaction disorders. The Rome IV criteria, a set of chronic or recurrent disorders characterized by gastrointestinal symptoms resulting from a combination of altered motility, visceral hyperalgesia, altered mucosal immune function, altered gut microbiota, and altered central nervous system processing. The current Pediatric Criteria Rome IV criteria used are divided into two age groups: newborns and children (0 to 3 years of age), and children and adolescents (4 to 18 years of age). In this text, we explore the experience of approaching infants and Preschoolers.

Conclusion: The Rome IV criteria for infants and preschoolers have enabled us to understand brain-gut interaction disorders better, thereby enriching our diagnostic capacity and treatment options for these children.

 Keywords: Rome IV Criteria; Brain-Gut Interaction Disorders; Infant; Preschoolers

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Nilton Carlos Machado., et al. “Brain-Gut Interaction Disorders in Infants and Preschoolers: How are we Finalizing the Practice of the Rome IV Criteria, and what are the Expectations for the Next Step?”. EC Paediatrics  14.10 (2025): 01-17.