EC Orthopaedics

Short Communication Volume 15 Issue 4 - 2024

Vitamin D Deficiency and Associated Autism Phenotypes

>Rosini Sergio1 and Molfetta Luigi2*

1Biomaterial Research Center, Livorno, Italy

2University of Genoa, DISC Department, School of Medical and Pharmaceutical Sciences, Research Center of Osteoporosis and Osteoarticular Pathologies, Genoa, Italy

*Corresponding Author: Molfetta Luigi, Professor, University of Genoa, DISC Department, School of Medical and Pharmaceutical Sciences, Research Center of Osteoporosis and Osteoarticular Pathologies, Genoa, Italy.
Received: April 04, 2024; Published: April 19, 2024



A number of studies have assessed the effects of VD supplementation in children. Special interest, however, has been devoted to the effects that adequate blood concentrations of Vit D exert during periods of pregnancy and lactation that require an adequate vitamin D status to avoid disturbances that may affect not only the musculoskeletal system but also the central nervous system.

Development Vit D deficiency (DVD) is associated with alterations in the dopaminergic neurotransmitter systems. In contrast, recently published animal experiments indicate that adult vitamin D (AVD) deficiency is associated with more subtle neurochemical and behavioral phenotypes.

Gestational vitamin D deficiency has been associated with autism-related traits in a large population-based sample as well in other neurological alterations. Because gestational vitamin D deficiency is readily preventable with safe, and accessible supplements, these candidate risks factor warrants closer attention.

 Keywords: Vitamin D; Autism; Pregnant Women; Gestational Deficiency

  1. Mazzoleni S., et al. “Effect of vitamin D3 seasonal supplementation with 1500 IU/day in north Italian children (DINOS study)”. Italian Journal of Pediatrics1 (2019): 18.
  2. Rajakumar K., et al. “Effect of vitamin D3 supplementation in black and in white children: A randomized, placebo-controlled trial”. Journal of Clinical Endocrinology and Metabolism 8 (2015): 3183-3192.
  3. Lewis RD., et al. “A randomized trial of vitamin D3 supplementation in children: Dose-response effects on vitamin D metabolites and calcium absorption”. Journal of Clinical Endocrinology and Metabolism 12 (2013): 4816-4825.
  4. Cui X., et al. “Vitamin D and the brain: key questions for future research”. Journal of Steroid Biochemistry and Molecular Biology 148 (2015): 305-309.
  5. Whitehouse AJ., et al. “Maternal vitamin D levels and the autism phenotype among offspring”. Journal of Autism and Developmental Disorders 7 (2013): 1495-1504.
  6. Whitehouse AJ., et al. “Maternal serum vitamin D levels during pregnancy and offspring neurocognitive development”. Pediatrics3 (2012): 485-493.
  7. Wang Z., et al. “The association between vitamin D status and autism spectrum disorder (ASD) a systematic review and meta-analysis”. Nutrients1 (2020): 86.
  8. Eyles DW., et al. “The association between neonatal vitamin D status and risk of schizophrenia”. Scientific Reports 1 (2018): 17692.
  9. Casamassima F., et al. “L-type calcium channels and psychiatric disorders: a brief review”. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 8 (2010): 1373-1390.
  10. Eyles DW., et al. “Vitamin D, effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease”. Frontiers in Neuroendocrinology 1 (2013): 47-64.
  11. Kittana M., et al. “The role of vitamin D supplementation in children with autism spectrum disorder: A narrative review”. Nutrients1 (2022): 26-31.
  12. Eyles DW., et al. “Distribution of the vitamin D receptor and 1alpha-hydroxylase in human brain”. Journal of Chemical Neuroanatomy 1 (2005): 21-30.

Rosini Sergio and Molfetta Luigi. "Vitamin D Deficiency and Associated Autism Phenotypes." EC Orthopaedics 15.4 (2024): 01-04.