EC Orthopaedics

Editorial Volume 17 Issue 5 - 2026

Fracture Related Infection (FRI): Navigating the Evolving Landscape of Definition, Diagnosis, and Management

Ranjith Kumar Yalamanchili, Deepankar Satapathy and Syed Ifthekar*

All India Institute of Medical Sciences, Bibinagar, Hyderabad, Telangana, India

*Corresponding Author: Syed Ifthekar, All India Institute of Medical Sciences, Bibinagar, Hyderabad, Telangana, India.
Received: June 29, 2026; Published: July 01, 2026



Fracture-related infection (FRI) represents one of the most challenging and debilitating complications in orthopaedic trauma surgery. With an estimated global incidence of approximately 1.8 million cases annually, FRI imposes a substantial burden on patients, healthcare systems, and economies. This editorial synthesizes contemporary evidence on the epidemiology, diagnostic workup, and multidisciplinary management of FRI.

Keywords: Fracture-Related Infection; FRI; DAIR; Implant-Associated Infection; Biofilm; Orthopaedic Trauma; Antimicrobial Therapy

  1. Metsemakers WJ., et al. “Fracture-related infection: a consensus on definition from an international expert group”. Injury3 (2018): 505-510.
  2. Govaert GAM., et al. “Fracture-Related Infection (FRI) Consensus Group. Diagnosing fracture-related infection: current concepts and recommendations”. Journal of Orthopaedic Trauma 1 (2020): 8-17.
  3. Rupp M., et al. “Fracture-related infection-epidemiology, etiology, diagnosis, prevention, and treatment”. Deutsches Ärzteblatt International 1 (2024): 17-24.
  4. Moriarty TF., et al. “Fracture-related infection”. Nature Reviews Disease Primers 1 (2022): 67.
  5. Rupp M., et al. “Fracture related infection-challenges in definition and diagnosis”. Journal of Orthopaedics 49 (2024): 38-41.
  6. He SY., et al. “Current concepts of fracture-related infection”. International Journal of Clinical Practice (2023): 4839701.
  7. Vanvelk N., et al. “Diagnosis of fracture-related infection in patients without clinical confirmatory criteria: an international retrospective cohort study”. Journal of Bone and Joint Infection 2 (2023): 133-142.
  8. Alt V., et al. “The FRI classification-a new classification of fracture-related infections”. Injury 11 (2024): 111831.
  9. Baddula AR., et al. “A case report of osteomyelitis of lower end of tibia and fibula as a complication of elastic rubber band syndrome (Dhaga Syndrome)”. Journal of Orthopaedic Case Reports 4 (2021): 56-58.
  10. Fonkoue L., et al. “Predictive factors for fracture-related infection in open tibial fractures in a sub-Saharan African setting”. Injury 7 (2023): 110816.
  11. Depypere M., et al. “The microbiological etiology of fracture-related infection”. Frontiers in Cellular and Infection Microbiology 12 (2022): 934485.
  12. Thompson E, Qureshi A. Pathogens in FRI-do bugs matter? An analysis of FRI studies to assess your enemy”. Journal of Orthopaedics 53 (2024): 59-72.
  13. Baertl S., et al. “The DAIR-procedure in fracture-related infection-when and how”. Injury6 (2024): 111977.
  14. Metsemakers WJ., et al. “General treatment principles for fracture-related infection: recommendations from an international expert group”. Archives of Orthopaedic and Trauma Surgery 8 (2020): 1013-1027.
  15. Kasha S., et al. “Design innovation and rationale of the intramedullary implants for treating Intertrochanteric fractures: A review”. Journal of Clinical Orthopaedics and Trauma 56 (2024): 102525.
  16. Lemans JVC., et al. “The diagnostic accuracy of 18F-FDG PET/CT in diagnosing fracture-related infections”. European Journal of Nuclear Medicine and Molecular Imaging 4 (2019): 999-1008.
  17. Marais LC., et al. “The surgical management of fracture-related infection: surgical strategy selection and the need for early surgical intervention”. Journal of Orthopaedics 50 (2024): 36-41.
  18. Srinivas Kasha and Ranjith Kumar Yalamanchili. “The Masquelet technique in an extruded talus injury after open peri-talar dislocation-A case report”. Trauma and Case Reports 36 (2021): 100559.
  19. Srinivas Kasha and Ranjith Kumar Yalamanchili. “Current overview on Masquelet technique”. Journal of Orthopaedic Association of South Indian States 2 (2021): 44-48.
  20. Morgenstern M., et al. “The influence of duration of infection on outcome of debridement and implant retention in fracture-related infection: a systematic review and critical appraisal”. Bone and Joint Journal 103-B.2 (2021): 213-221.
  21. Suh GA., et al. “Phage therapy as a novel therapeutic for the treatment of bone and joint infections”. Clinical Infectious Diseases5 (2023): S407-S415.
  22. Walter N., et al. “Long-term patient-related quality of life after fracture-related infections of the long bones”. Bone and Joint Research 5 (2021): 321-327.

Syed Ifthekar., et al. “Fracture Related Infection (FRI): Navigating the Evolving Landscape of Definition, Diagnosis, and Manage- ment”. EC Orthopaedics 17.5 (2026): 01-10.

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