EC Orthopaedics

Mini Review Volume 16 Issue 7 - 2025

Comparative Aspects of Bone and Cartilage Aging within the Joint Environment

Rosini Sergio1, Stefano Rosini2, Molfetta Francesco3 and Molfetta Luigi4*

1Biomaterial Research Center, Livorno, Italy

2Smile-Restyle, Livorno, Italy

3DINOGMI Department, School of Medical and Pharmaceutical Sciences, Research Center of Osteoporosis and Osteoarticular Pathologies, University of Genoa, Genoa, Italy

4DISC Department, School of Medical and Pharmaceutical Sciences, Research Center of Osteoporosis and Osteoarticular Pathologies, University of Genoa, Genoa, Italy

*Corresponding Author: Molfetta Luigi, Professor, DISC Department, School of Medical and Pharmaceutical Sciences, Research Center of Osteoporosis and Osteoarticular Pathologies, University of Genoa, Genoa, Italy.
Received: October 16, 2025; Published: November 26, 2025




Bone and cartilage, although distinct in structure and function, share a common mesenchymal origin and are closely interconnected within the joint unit. Aging affects both tissues through convergent cellular and molecular mechanisms, including oxidative stress, chronic low-grade inflammation, and impaired mechanotransduction. These processes result in the gradual loss of structural integrity and regenerative capacity, contributing to the onset of osteoarthritis and other degenerative joint diseases. Understanding the shared pathways of skeletal aging may open new perspectives for integrated therapeutic approaches.

 Keywords: Aging; Cartilage; Osteoarthritis; Bone; Osteoarthritis

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Molfetta Luigi., et al. “Comparative Aspects of Bone and Cartilage Aging within the Joint Environment”. EC Orthopaedics  16.7 (2025): 01-05.

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