EC Neurology

Research Article Volume 15 Issue 4 - 2023

Stress Hyperglycemia as a Predictor for Outcome of Non-Diabetic Patients with Acute Cerebrovascular Disease - A Study of 490 Patients

Christiyan Naydenov1*, Ivan Mindov2, Teodora Manolova1 and Antoaneta Yordanova3

1Department of Neurology and Psychiatry, Faculty of Medicine, Trakia University, Bulgaria

2Department of Neurosurgery, Faculty of Medicine, Trakia University, Bulgaria

3Department of Social Medicine, Healthcare Management and Disaster Medicine, Trakia University, Bulgaria

*Corresponding Author: Christiyan Naydenov, Department of Neurology and Psychiatry, Faculty of Medicine, Trakia University, Bulgaria.
Received: March 03, 2023; Published: March 12, 2023

Stress hyperglycemia is a condition characterized by high blood sugar levels that occur in response to physical or emotional stress. It is common among hospitalized individuals and those undergoing surgery. While stress hyperglycemia is typically temporary, it can still have negative effects on the body. Studies have shown that stress hyperglycemia is associated with worse clinical outcomes in patients with acute stroke. The retrospective study aimed to examine the association between stress hyperglycemia and stroke outcome using data that had already been collected. The study included 490 patients and found that stress hyperglycemia was associated with higher mortality rates in patients with acute stroke. The study concluded that stress hyperglycemia could be used as a predictor of stroke outcome. The results of the study were consistent with previous research on stress hyperglycemia and stroke outcome.

Keywords: Blood Sugar Level; Stress Hyperglycemia; Cerebrovascular Disease Outcome; Acute Stroke Prognostic Factor

  1. Cai ZM., et al. “Fasting blood glucose-to-glycated hemoglobin ratio and all-cause mortality among Chinese in-hospital patients with acute stroke: a 12-month follow-up study”. BMC Geriatrics1 (2022): 508.
  2. Giuseppe De Luca., et al. “Stone, for the DESERT cooperation; Impact of Diabetes on Long-Term Outcome After Primary Angioplasty: Insights from the DESERT cooperation”. Diabetes Care4 (2013): 1020-1025.
  3. Patwary MSA., et al. “Glycaemic Status in Acute Stroke in Nondiabetic Patient”. Journal of Medicine1 (2021): 22-26.
  4. Zhu B., et al. “Stress Hyperglycemia and Outcome of Non-diabetic Patients After Acute Ischemic Stroke”. Frontiers in Neurology 10 (2019): 1003.
  5. Habibur Rahaman., et al. “A study on incidence of stress hyperglycemia in acute ischemic stroke in non-diabetic patients and its prognostic significance”. Asian Journal of Medical Sciences12 (2022): 117-122.
  6. Bruno A., et al. “Admission glucose level and clinical outcomes in the NINDS rt-PA Stroke Trial”. Neurology9 (2002): 1360-1365.
  7. Muscari A., et al. “Prognostic significance of diabetes and stress hyperglycemia in acute stroke patients”. Diabetology and Metabolic Syndrome1 (2022): 126.
  8. Capes SE., et al. “Stress hyperglycemia and prognosis of stroke in nondiabetic and diabetic patients: a systematic overview”. Stroke10 (2001): 2426-2432.
  9. Uyttenboogaart M., et al. “Moderate hyperglycaemia is associated with favourable outcome in acute lacunar stroke”. Brain4 (2007): 1626-1630.
  10. Jin H., et al. “Persistent hyperglycemia is associated with poor outcome in acute intracerebral hemorrhage: a prospective cohort study”. Mediators of Inflammation (2014): 618180.
  11. Won SY., et al. “Admission hyperglycemia is associated with a poor outcome in critically ill patients with acute stroke”. Journal of Stroke and Cerebrovascular Diseases2 (2015): 400-406.
  12. Zou X., et al. “The relationship between admission hyperglycemia and outcomes in different subtypes of acute ischemic stroke”. Medicine42 (2017): e8029.
  13. Johnston KC., et al. “Admission glucose levels predict mortality and hemorrhagic transformation in patients with acute ischemic stroke”. Stroke1 (2010): 49-53.
  14. Alvarez-Sabín J., et al. “Impact of admission hyperglycemia on stroke outcome after thrombolysis: risk stratification in relation to time to reperfusion”. Stroke11-1 (2004): 2493-2498.
  15. Baird TA., et al. “Persistent poststroke hyperglycemia is independently associated with infarct expansion and worse clinical outcome”. Stroke9 (2003): 2208-2214.
  16. Rosso C., et al. “Hyperglycemia and the fate of apparent diffusion coefficient-defined infarcts in acute ischemic stroke”. Stroke2 (2012): 424-429.
  17. Ji R., et al. “Stroke in the very elderly: risk factors, clinical features, and outcomes in patients aged ≥85 years”. Aging and Disease5 (2014): 363-371.
  18. Song EC., et al. “Hyperglycemia exacerbates brain edema and perihematomal cell death after intracerebral hemorrhage”. Stroke2 (2013): 545-548.
  19. Wang C., et al. “Predictive value of persistent stress hyperglycemia for severe functional disability in acute ischemic stroke”. Journal of Stroke and Cerebrovascular Diseases6 (2016): 1316-1321.
  20. Zhang J., et al. “The association between stress hyperglycemia and unfavorable outcomes in patients with anterior circulation stroke after mechanical thrombectomy”. Frontiers in Aging Neuroscience 14 (2023): 1071377.
  21. Konstantinos Tziomalos., et al. “Stress hyperglycemia and acute ischemic stroke in-hospital outcome”. Metabolism - Clinical and Experimental 67 (2017): 99-105.

Christiyan Naydenov., et al. “Stress Hyperglycemia as a Predictor for Outcome of Non-Diabetic Patients with Acute Cerebrovascular Disease - A Study of 490 Patients”. EC Neurology  15.4 (2023): 40-44.