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Mucinous cystadenocarcinoma testis is a neoplasm articulated of ovarian subtype of surface epithelium. The testicular carcinoma principally expounds mucinous differentiation. Mucinous cystadenocarcinoma configures as an extremely exceptional, testicular neoplasm. Tumour commonly emerges within middle aged and elderly, male subjects. Mean age of disease emergence is 62 years [1,2]. Of obscure genesis, the ovarian subtype of surface epithelial tumour may arise within testis and paratestis. Tumefaction is posited to be derived from Müllerian epithelial remnants or may arise due to metaplasia of mesothelium layering tunica vaginalis [2,3]. Clinically, individuals may represent with painless enlargement of the scrotum. Alternatively, minimal tenderness of scrotum may emerge [3,4]. Grossly, neoplasm emerges as a mucinous, cystic mass adjoining and replacing testicular parenchyma [3,4]. Upon microscopy, the malignant neoplasm represents as a well to moderately differentiated, cystic neoplasm displaying mucinous differentiation. Tumefaction is comprised of congregation of cohesive, irregular, back to back glands commingled with complex articulations of fine, elongated papillary structures. The neoplastic glandular component is layered with ciliated cuboidal to columnar epithelial cells alternating with mucin rich goblet cells. Intervening stroma is minimal [4,5]. Papillary structures delineate atypical cells impregnated with overlapping, hyperchromatic, elongated nuclei with coarse nuclear chromatin and enhanced nucleocytoplasmic ratio. Cystic spaces are pervaded with mucin, fibrino-purulent substance and degenerative cellular debris [4,5]. Psammoma bodies and focal calcification may be discerned. Focal mucin extravasation may ensue [5,6].

1. Agrawal H., et al. “Mucinous cystadenoma arising in post-treatment non-seminomatous germ cell tumor: a rare occurrence”. Cureus 16.11 (2024): e74375.
2. Ramakrishnan V., et al. “Primary testicular mucinous adenocarcinoma-a case report and review of literature”. Indian Journal of Surgical Oncology 15.1 (2024): 125-128.
3. Tanriverdi O., et al. “Management of a patient with primary mucinous testicular adenocarcinoma as a rare case with adjuvant and metastatic sequential treatments”. Journal of Oncology Pharmacy Practice 26.6 (2020): 1520-1523.
4. Gaddam SJ and Chesnut GT. “Testicle cancer”. Stat Pearls International. Treasure Island, Florida (2023).
5. Moch H., et al. “The 2016 WHO classification of tumours of the urinary system and male genital organs-part A: renal, penile, and testicular tumours”. European Urology 70.1 (2016): 93-105.
6. Chahal D., et al. “Mucinous cystic tumour of low malignant potential presenting in a patient with prior non-seminatous germ cell tumour”. Canadian Urological Association Journal 9.9-10 (2015): E750-E753.
7. Lei H., et al. “Primary mucinous adenocarcinoma of the testis: a case report and review of the literature”. Research Square (2020).
8. Mano R., et al. “Current controversies on the role of retroperitoneal lymphadenectomy for testicular cancer”. Urologic Oncology 37.3 (2019): 209-218.
9. Di Franco C., et al. “Primary paratesticular mucinous “ovarian-type” adenocarcinoma: a rare case of scrotal tumor in a patient with history of bilateral cryptorchidism”. World Journal of Nephrology and Urology 4.4 (2015): 260-263.
10. Image 1 Courtesy: Wikipedia.
11. Image 2 Courtesy: Science Direct.