EC Neurology

Case Series Volume 17 Issue 4 - 2025

Personalized rTMS in Pediatric Patients with Autism: A Case Series Exploring Therapeutic Outcomes

Kavya Mohankumar1,2*, Lakshmi Sanjay3, Sai Kiran Kumar3, Charles Vigilia1, Shaurya Mahajan1, Siddharth Karthikeya1,4, Kevin T Murphy3,5, Kenneth Blum6-11, Kai-Uwe Lewandrowski12-14, Rajendra D Badgaiyan15, Mark S Gold16 and Keerthy Sunder1,3,6,17

1Division of Clinical Neuromodulation Research, Karma Doctors, Palm Springs, CA, USA
2Brown University School of Public Health, Providence, RI, USA
3Karma Peak Brain, Chennai, TN, India
4University of California Irvine, CA, USA
5Division of Personalized Neuromodulations, PeakLogic, LLC, Del Mar, CA, USA
6Sunder Foundation, Palm Springs, CA, USA
7Western University Health Science Centers, Graduate College, Pompano, CA, USA
8Department of Psychiatry, University of Vermont, Burlington, VT, USA
9Institute of Psychology, Eotvos Loránd University, Budapest, Hungary
10Department of Psychiatry, Wright University Boonshoft School of Medicine, Dayton, OH, USA
11Centre for Genomics and Applied Gene Technology, Institute of Integrative Omics and Applied Biotechnology, Nonakuri, Purba Medinipur, West Bengal, India
12Division of Personalized Pain Therapy Research, Center for Advanced Spine Care of Southern Arizona, Tucson, Arizona, United States of America
13Department of Orthopaedics, Fundación Universitaria Sanitas, Bogotá, Colombia
14Department of Orthopedics, Hospital Universitário Gaffree Guinle Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, Brazil
15Department of Psychiatry, Mt. Sinai University School of Medicine, New York, NY, USA
16Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA
17Department of Psychiatry, University of California Riverside School of Medicine, CA, USA

*Corresponding Author: Kavya Mohankumar, Division of Clinical Neuromodulation Research, Karma Doctors, Palm Springs, CA, USA.
Received: February 12, 2025; Published: March 13, 2025



Autism spectrum disorder (ASD) is a multifaceted neurodevelopmental condition which has been previously linked to disruptions in the excitatory and inhibitory (E/I) balance of the brain. Personalized repetitive transcranial magnetic stimulation (PrTMS®) guided by spectral EEG has gained traction as a novel treatment option targeting these neurophysiological disturbances. This case series evaluates the therapeutic outcomes of PrTMS® in three pediatric patients with ASD. Over six weeks, participants received daily PrTMS® sessions, with weekly adjustments to treatment protocols informed by their spectral EEG findings and psychometric assessments. On average, CARS scores decreased by 7.5 points across all patients by the end of treatment, indicating improvements in autism-related symptoms. Patients 1 and 2 exhibited a 9-point reduction in ADHD symptoms, as measured by the NICHQ Vanderbilt Assessment Scale. These results align with prior research, suggesting that PrTMS® may effectively regulate cortical activity and restore E/I balance, contributing to clinical improvements in ASD. Despite the small sample size, this study underscores the potential of PrTMS® as a targeted intervention for ASD, meriting further exploration in studies of larger scales

 Keywords: Personalized Repetitive Transcranial Magnetic Stimulation (PrTMS®); Repetitive Transcranial Magnetic Stimulation (rTMS); Neuromodulation; Autism; Autism Spectrum Disorder; Spectral EEG; Spectral Electroencephalogram; CARS (Childhood Autism Rating Scale); NICHQ Vanderbilt Assessment Scale; Alpha Brainwave Activity

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Kavya Mohankumar.,et al. “Personalized rTMS in Pediatric Patients with Autism: A Case Series Exploring Therapeutic Outcomes”. EC Neurology   17.4 (2025): 01-06.

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