EC Neurology

Review Article Volume 17 Issue 1 - 2025

Passing the Wave - How Does the Action Potential Pulse Pass Between Axons and Dendrites?

William Winlow*, Gianluca Polese and Andrew S Johnson

Department of Biology, University of Napoli Federico II, Naples, Italy

*Corresponding Author: William Winlow, Department of Biology, University of Napoli Federico II, Naples, Italy.
Received: December 04, 2024; Published: December 24, 2024



The action potential is an ensemble of three inseparable concurrent states, one of which is a soliton known as the action potential pulse (APPulse). Here we consider how the pulse may pass from one neuron to another. On the basis of the evidence we present here our working hypothesis is that the APPulse is passed mechanically from presynaptic terminals to postsynaptic dendrites via surrounding astrocytes. These cells are strongly connected to both pre- and postsynaptic neurons by synaptic adhesion molecules: cadherins and nectins.

 Keywords: Action Potential; Action Potential Pulse; Hodgkin and Huxley; Computational Action Potential; Puncta Adherentia Junctions

  1. Hodgkin AL and Huxley AF. “A quantitative description of membrane current and its application to conduction and excitation in nerve”. Journal of Physiology 4 (1952): 500-544.
  2. Winlow W and Johnson AS. “Nerve impulses have three interdependent functions: Communication, modulation, and computation”. Bioelectricity3 (2021): 161-170.
  3. Johnson AS and Winlow W. “The soliton and the action potential: primary elements underlying sentience”. Frontiers in Physiology 9 (2018): 779.
  4. Johnson AS and Winlow W. “Does the brain function as a quantum phase computer using phase ternary computation?” Frontiers in Physiology 12 (2021): 572041.
  5. Winlow W and Johnson AS. “The action potential peak is not suitable for computational modelling and coding in the brain”. EC Neurology4 (2020): 46-48.
  6. Johnson AS and Winlow W. “Computing action potentials by phase interference in realistic neural networks”. EC Neurology3 (2017): 123-134.
  7. Johnson AS and Winlow W. “Are neural transactions in the retina performed by phase ternary computation?” Annals of Behavioural Neuroscience1 (2019): 223-236.
  8. Johnson AS. “The coupled action potential pulse (APPulse)-Neural network efficiency from a synchronised oscillating lipid pulse Hodgkin Huxley action potential”. EC Neurology 2 (2015): 94-101.
  9. Winlow W., et al. “Classical and non-classical neural communications”. OBM Neurobiology3 (2023): 1-11.
  10. Winlow W. “The plastic nature of action potentials”. In: The cellular basis of neuronal plasticity - physiology, morphology and biochemistry of molluscan neurons, Ed A.G.M. Bulloch. Manchester University Press, UK (1989): 3-27.
  11. Heimburg T and Jackson AD. “On soliton propagation in biomembranes and nerves”. Proceedings of the National Academy of Sciences of the United States of America 28 (2005): 9790-9795.
  12. El Hady A and Machta B. “Mechanical surface waves accompany action potential propagation”. Nature Communications 6 (2015): 6697.
  13. Katz B and Miledi R. “The measurement of synaptic delay, and the time course of acetylcholine release at the neuromuscular junction”. Proceedings of the Royal Society B: Biological Sciences 161 (1965): 483-495.
  14. Kettenmann H., et al. “Physiology of microglia”. Physiological Reviews 2 (2011): 461-553.
  15. Togashi H., et al. “Cell adhesion molecules in the central nervous system”. Cell Adhesion and Migration1 (2009): 29-35.
  16. Araque A., et al. “Tripartite synapses: glia the unacknowledged partner”. Trends in Neurosciences 5 (1999): 208-215.
  17. Brini M., et al. “Neuronal calcium signaling function and dysfunction”. Cellular and Molecular Life Sciences 15 (2014): 2787-2814.
  18. Takeichi M. “Functional correlation between cell adhesive properties and some cell surface proteins”. Journal of Cell Biology 2.1 (1977): 464-474.
  19. Mizutani R., et al. “Structural diverseness of neurons between brain areas and between cases”. Translational Psychiatry1 (2021): 49.

William Winlow., et al. “Passing the Wave - How Does the Action Potential Pulse Pass Between Axons and Dendrites?”. EC Neurology  17.1 (2025): 01-05.