EC Neurology

Review Article Volume 17 Issue 10 - 2025

Oxidative Stress and Mitochondrial Dysfunction in Neurotoxic Damage

A’aesha Mohammad Mahmoud Qasem1 and Ahed J Alkhatib2,3,4*

1Aljawabreh Trading Est, Jordan

2Retired, Department of Legal Medicine, Toxicology and Forensic Medicine, Jordan University of Science and Technology, Jordan

3Department of Medicine and Critical Care, Department of Philosophy, Academician Secretary of Department of Sociology, International Mariinskaya Academy, Jordan

4Cypress International Institute University, Texas, USA

*Corresponding Author: Ahed J Alkhatib, Retired, Department of Legal Medicine, Toxicology and Forensic Medicine, Jordan University of Science and Technology, Jordan and Department of Medicine and Critical Care, Department of Philosophy, Academician Secretary of Department of Sociology, International Mariinskaya Academy, Jordan and Cypress International Institute University, Texas, USA.
Received: September 12, 2025; Published: October 10, 2025



The breakdown of the body's mitochondria and cells is a big cause of a huge range of illnesses. The brain is very sensitive to damages caused by oxygen that’s in excess, because of many fatty substances or lipids present, as well as limited antioxidant defense mechanism. Enabling there to be too many toxic molecules called ROS, origin a bodily imbalance and therefore have a lot of bad effects on our cell "origin" and DNA as well. As the major energy producers in a cell, mitochondria are both the roots of oxidative stress as well as being themselves affected by it. Exposure to toxins like lead and mercury really messes with our brain cells, it slows down the brains energy reservoir, from function that manufactures enzyme. These changes increase brain damage by reaching dangerous cellular developments and by messing incidents in the system of mailing signals between the brain's connections. There is proof that imparted damage goes from the muscles to the brain itself through a harmful loop. To find new approaches to treatment and identify symptoms, and quote; oxidative stress simultaneously contributes to mitochondrial dysfunction and quote; is something mankind needs. Doctors feel that certain medicine or methods can help protect the human brain to be safe. New focus on helping treatment to live the outside life with a stronger environment so the essence of what is going on don’t die.

 Keywords: Oxidative Stress; Mitochondrial Dysfunction; Neurotoxicity; Reactive Oxygen Species; Neurodegeneration

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A’aesha Mohammad Mahmoud and Ahed J Alkhatib. “Oxidative Stress and Mitochondrial Dysfunction in Neurotoxic Damage”. EC Neurology  17.10 (2025): 01-10.

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