EC Neurology

Review Article Volume 17 Issue 10 - 2025

Gut-Brain Axis and Microbiota's Role in Neurotoxicity Modulation

Ahed J Alkhatib1,2,3* and A’aesha Mohammad Mahmoud Qasem4

1Retired, Department of Legal Medicine, Toxicology and Forensic Medicine, Jordan University of Science and Technology, Jordan

2Department of Medicine and Critical Care, Department of Philosophy, Academician Secretary of Department of Sociology, International Mariinskaya Academy, Jordan

3Cypress International Institute University, Texas, USA

4Aljawabreh Trading Est, Jordan

*Corresponding Author: Ahed J Alkhatib, Retired, Department of Legal Medicine, Toxicology and Forensic Medicine, Jordan University of Science and Technology, Jordan and Department of Medicine and Critical Care, Department of Philosophy, Academician Secretary of Department of Sociology, International Mariinskaya Academy, Jordan and Cypress International Institute University, Texas, USA.
Received: September 12, 2025; Published: October 13, 2025



The gut-brain axis is a complex communication system that connects the gastrointestinal tract and the central nervous system. It is bidirectional in nature. Also, it occurs through neural, hormonal and immune pathways.

Research is starting to show that gut microbiota affects certain neurotoxic effects by controlling inflammation, maintaining the blood-brain barrier, and making neurotransmitters. The changes in the microbes of the gut cause the condition named dysbiosis. If it is disturbed due to heavy metals, pesticides, drugs and chemicals, it would interfere with the neurotoxic response. Microbial metabolites like SCFAs, bile acids, and tryptophan derivatives can potentiate or antagonize neurotoxicity by regulating oxidative stress, excitotoxicity and immune activation. Also, new findings show that probiotics, prebiotics, and fecal microbiota transplantation treatments may reverse neurotoxic damage and neurophysiological balance. Even though tests have helped us understand this well, it is still hard to know for sure that these things happen in humans. The growing area of microbiome science and its association with the field of neurotoxicology has tremendous importance in sub-fields of prevention, diagnostics and personalized therapeutics. More is known about the link between our gut microflora and the brain, will open new ways to reduce neurotoxicity and achieve better neurological health.

 Keywords: Gut-Brain Axis; Microbiota; Neurotoxicity; Neuroinflammation; Dysbiosis

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Ahed J Alkhatib and A’aesha Mohammad Mahmoud Qasem. “Gut-Brain Axis and Microbiota's Role in Neurotoxicity Modulation”. EC Neurology  17.10 (2025): 01-06.

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