EC Neurology

Objective: This research determined the effects of antioxidant, secoisolariciresinol diglucoside (SDG), found in flaxseed, on beta-amyloid (BA)-induced oxidative stress in PC12 cells.

Methods: Cells were treated with 50 or 100 µM SDG, 100 U/ml superoxide dismutase (SOD), or 100 U/ml catalase (CAT). Then, cells were treated with 10 µM BA. Reactive oxygen species (ROS) accumulation, cell damage, and cell viability were determined.

Results:SDG decreased ROS levels compared to control cells. BA-exposed cells treated with antioxidants had no differences in cell damage and viability compared to controls, indicating protective effects.

Conclusion: SDG shows promise for reducing oxidative stress caused by beta-amyloid in cells.

Keywords: Oxidative Stress; Beta-Amyloid; Secoisolariciresinol Diglucoside; Flaxseed; Linum usitatissimum; PC-12

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