EC Neurology

Study of processes occurring in tumor tissues during tumor progression in the postoperative period investigated by studying inflammation of tumor and non-tumor nature. Verapamil hydrochloride, as shown in our studies, changes the transmembrane potential of tumor and peripheral blood cells of the tumor-bearing organism. Previously shown that adding verapamil hydrochloride to blood cells without plasma in a dilution of 10,000 times increases the indices of surface plasmon resonance (SPR) indirectly determines blood cell aggregation level on Plasmon device for malignant gliomas. A dilution of verapamil hydrochloride by 100 times this indices increases in case of traumatic brain injuries or other inflammatory processes of a non-tumor nature. The work used these two dilutions for correlation between the cellular transmembrane potential mediated by SPR indices and quantitative changes in the cellular pool derived from mesenchymal stem cells. As is known, peripheral blood cells are an active mechanism in the tumor microenvironment, which affects its progression in the postoperative period. For the first time, it was separated SPR indices on the blood of patients in vitro with total and subtotal tumor removal, confirmed by clinical examinations. This approach makes possible clearly distinguish the mechanisms of progression by participation of blood cells

 Keywords: Glioma; Blood Cells; SPR Indices; Radicalism of Tumor Removal

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