EC Neurology

Traumatic Brain Injury (TBI) is frequently associated with profound autonomic dysregulation, characterized by persistent sympathetic dominance and diminished parasympathetic activity. This preliminary observational study explores the potential of a multi-modal therapeutic approach-combining mild-hyperbaric therapy (MHBT), photobiomodulation (PBM), and molecular hydrogen therapy (MH)-to improve autonomic nervous system (ANS) regulation in TBI patients. Utilizing heart rate variability (HRV) metrics, particularly the low-frequency/high-frequency (LF/HF) ratio, the investigation observed reductions in sympathetic dominance and signs of improved parasympathetic activity across ten TBI patients (6 males, 4 females; mean age: 53.4 ± 8.2 years). These early findings suggest that multi-modal therapy may serve as a supportive, non-pharmacological intervention for enhancing autonomic regulation in TBI patients.

 Keywords: Traumatic Brain Injury; Autonomic Dysregulation; Sympathetic Dominance; Heart Rate Variability; Multi-Modal Therapy

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