EC Neurology

Introduction

The commonly reported neurological adverse effects following the administration of different types of COVID-19 are often mild and transient. However, vaccines can induce unexpected severe complications. We reviewed 37 published case reports across the world about the neurological complications following COVID-19 vaccination, explaining their presentations, findings, diagnosis and the patients prognosis. These complications include acute encephalitis, acute transverse myelitis, Gillian-Barre syndrome subtypes, cranial nerves neuropathies, myasthenia gravis and myositis, exacerbation of multiple sclerosis and development of refractory status epilepticus. We will focus in this article specifically on Guillain-Barré syndrome caused by the vaccines [1-5].

1. Waheed S., et al. “Neurological Complications of COVID-19: Guillain-Barre Syndrome Following Pfizer COVID-19 Vaccine”. Cureus2 (2021): e13426.
2. Nasuelli NA., et al. “A case of acute demyelinating polyradiculoneuropathy with bilateral facial palsy after ChAdOx1 nCoV-19 vaccine”. Neurological Sciences11 (2021): 4747-4749.
3. Biswas A., et al. “Post coronavirus disease-2019 vaccination Guillain-Barré syndrome”. Indian Journal of Public Health 65 (2021): 422-424.
4. Maramattom BV., et al. “Guillain-Barré Syndrome following ChAdOx1-S/nCoV-19 Vaccine”. Annals of Neurology2 (2021): 312-314.
5. Jasti AK., et al. “Guillain-Barré syndrome: causes, immunopathogenic mechanisms and treatment”. Expert Review of Clinical Immunology11 (2016): 1175-1189.