Review Article Volume 22 Issue 2 - 2026

The Impact of Excessive Paracetamol Use on the Human Body: A Comprehensive Review

Priyanka Singh1, Puspa Mishra2 and Gopal Krishna Gupta3*

1Department of Sociology, Jananayak Chandrashekhar University, Ballia, Uttar Pradesh, India

2Department of Social Work, Jananayak Chandrashekhar University, Ballia, Uttar Pradesh, India

3Department of Physics, Jananayak Chandrashekhar University, Ballia, Uttar Pradesh, India

*Corresponding Author: Gopal Krishna Gupta, Department of Physics, Jananayak Chandrashekhar University, Ballia, Uttar Pradesh, India.
Received: December 05, 2025; Published: January 31, 2026



Paracetamol, also known as acetaminophen, is one of the most widely used over-the-counter analgesics and antipyretics globally. While generally considered safe when used as directed, excessive or prolonged use of paracetamol can lead to adverse effects on various organ systems within the human body. This comprehensive review explores the physiological mechanisms underlying paracetamol toxicity, its effects on different organs, risk factors for overdose, diagnostic methods, and potential management strategies.

 Keywords: Paracetamol; Human Body; Overdose; Toxicity; N-Acetyl-P-Benzoquinone Imine (NAPQI)

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Gopal Krishna Gupta., et al. “The Impact of Excessive Paracetamol Use on the Human Body: A Comprehensive Review”. EC Microbiology  22.2 (2026): 01-11.