EC Microbiology

Keywords: Tuberculosis; Whole Genome Sequencing; Multi-Drug Resistant TB; End TB

Abbreviations

TB: Tuberculosis; WGS: Whole Genome Sequencing; WHO: World Health Organization; MDR-TB: Multidrug Resistant TB; XDR-TB: Extremely Drug-Resistant; PMDT: Programmatic Management of Drug-Resistant TB; DST: Drug-Sensitivity Test; CDST: Culture-Drug Sensitivity; RR: Rifampicin Resistance; RRDR: Rifampicin Resistance Defining Region; NGS: Next Generation Sequencing; PZA: Pyrazinamide; INH: Isoniazid; RIF: Rifampicin; MIC: Minimum Inhibitory Concentration; MGIT: Mycobacterial Growth Indicator Tube; TA: Turn-Around-Time

Tuberculosis (TB) affects millions every year, causing great morbidity and mortality worldwide (approximately 1.4 million lives in 2021) [1]. Despite being preventable and curable, TB still remains a major challenge to public health, with a large number of patients failing to respond to standard treatment. TB dramatically affects the quality-of-life of the patients, and also raises many socio-economic issues especially in medium- and high-burden regions like India, Pakistan, China, Indonesia.

1. Global tuberculosis report (2022).
2. Global tuberculosis report.
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5. Jiang J., et al. “Head-to-head comparison of the diagnostic accuracy of Xpert MTB/RIF and Xpert MTB/RIF Ultra for tuberculosis: a meta-analysis”. Infectious Diseases11 (2020): 763-775.
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