EC Microbiology

Guest Editorial Volume 19 Issue 6 - 2023

TB-Whole Genome Sequencing Bridging the Diagnostic Gaps for Effective Treatment

Rajendra Prasad1* and Aparna Bhanushali2

1Director Medical Education and Professor, Pulmonary Medicine, Era’s Lucknow Medical College and Hospital, Era University Lucknow, India

2Head-Growth and Scientific Support, Haystack Analytics Pvt Ltd, Society for Innovation and Entrepreneurship, Indian Institute of Technology-Mumbai, India

*Corresponding Author: Rajendra Prasad, Director Medical Education and Professor, Pulmonary Medicine, Era’s Lucknow Medical College and Hospital, Era University Lucknow, India.
Received: June 01, 2023; Published: June 22, 2023



Keywords: Tuberculosis; Whole Genome Sequencing; Multi-Drug Resistant TB; End TB

Abbreviations

TB: Tuberculosis; WGS: Whole Genome Sequencing; WHO: World Health Organization; MDR-TB: Multidrug Resistant TB; XDR-TB: Extremely Drug-Resistant; PMDT: Programmatic Management of Drug-Resistant TB; DST: Drug-Sensitivity Test; CDST: Culture-Drug Sensitivity; RR: Rifampicin Resistance; RRDR: Rifampicin Resistance Defining Region; NGS: Next Generation Sequencing; PZA: Pyrazinamide; INH: Isoniazid; RIF: Rifampicin; MIC: Minimum Inhibitory Concentration; MGIT: Mycobacterial Growth Indicator Tube; TA: Turn-Around-Time

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Tuberculosis (TB) affects millions every year, causing great morbidity and mortality worldwide (approximately 1.4 million lives in 2021) [1]. Despite being preventable and curable, TB still remains a major challenge to public health, with a large number of patients failing to respond to standard treatment. TB dramatically affects the quality-of-life of the patients, and also raises many socio-economic issues especially in medium- and high-burden regions like India, Pakistan, China, Indonesia.

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Rajendra Prasad and Aparna Bhanushali. “TB-Whole Genome Sequencing Bridging the Diagnostic Gaps for Effective Treatment”. EC Microbiology  19.6 (2023): 01-03.